2024-03-28T18:41:24Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00019307
2022-12-15T03:50:13Z
453:456
471:537:538:1149
磁気共鳴法を用いた脳神経活動の解析に関する研究
磁気共鳴法を用いた脳神経活動の解析に関する研究
Magnetic Resonance Study on the Analysis of Brain Function
渡邊, 浩之
brain function
MRS
FMRI
lactate
photic stimulation
脳機能
MR スペクトロスコピー
MR 機能画像
乳酸
光刺激
Magnetic resonance spectroscopy and imaging were applied to study human brain functions. In the present study, localized brain proton MR spectra and T_2* weighted MR images were acquired in the occipital visual cortex under photic stimulation (PS) from normal volunteers, and patients with migraine and mitochondrial encephalomyopathies (Kearns-Sayre syndrome) (KSS) using whole-body 1.5T clinical MR system. In the controls, lactate elevation was detected after the onset of PS. With continued PS, there was a decrease from the maximum. After PS was stopped, the lactate decreased almost to the baseline value. These results are consistent with the view that PS activated brain visual cortex, which stimulated glycolysis more predominantly than oxidative pathway. In the patients with migraine and KSS, the resting values of occipital lobe cortex lactate were significantly higher than those of controls. Furthermore, lactate values in KSS were significantly higher than those of migraine. However PS did not increase lactate significantly suggesting the blunted glycolysis in the impaired oxidative metabolism. The T_2* weighted MR images of the occipital visual cortex of human brain were studied by means of fast low-angle shot (FLASH). Among normal volunteers, elevation of image intensity up to 2% was observed in primary and associative visual cortex. After the PS was turned off, the MR signal fell below the pre-PS baseline level. In the patient with basilar migraine, MR signal change was smaller than those of normal volunteers, which may be understood as a hyporeactivity of vessels.
新潟医学会
1994-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/38289
https://niigata-u.repo.nii.ac.jp/records/19307
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
108
6
450
459
https://niigata-u.repo.nii.ac.jp/record/19307/files/108(6)_450-459.pdf
application/pdf
2.6 MB
2019-08-08