2024-03-29T11:16:20Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00018068
2022-12-15T03:49:19Z
453:456
471:537:538:1128
1) 脳における血管新生のメカニズムに関する検討 : 培養細胞(内皮, 腫瘍, アストロサイト等)を利用したアプローチ(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)
1) 脳における血管新生のメカニズムに関する検討 : 培養細胞(内皮, 腫瘍, アストロサイト等)を利用したアプローチ(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)
The Mechanism of Neovascularization in Brain : in Vitro Study Using Cultured Cells (Recent Topics in Vascular Biology)
皆河, 崇志
相場, 豊隆
新井田, 広仁
藤井, 幸彦
田中, 隆一
cultured endothelial cell
neovascularization
blood-brain barrier
brain
培養内皮細胞
血管新生
血液脳関門
脳
The mechanism of neovascularization in brain was investigated in vitro. Cultured microvascular endothelial cells, astrocytes, pericytes and glioma cells from brain were used in this study. Proliferation of endothelial cells was stimulated by type 1 collagen and moderate hypoxia. Conditioned media from glioma cells failed to fascilitate the growth of endothelial cells. Differentiation of endothelial cells, demonstrated by the formation of capillatry-like structure was stimulated the existence of type 1 collagen. Glioma cells also stimulated the formation of capillary-like structures. Astrocytes migrated and attached to the capillary-like structures, and the formation of blood-brain barrier, proved by the induction of tight junction was observed 9 days after the attactment. Pericytes also migrated and attached to the capillary-like structures.
新潟医学会
1996-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/43111
https://niigata-u.repo.nii.ac.jp/records/18068
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
110
6
197
202
https://niigata-u.repo.nii.ac.jp/record/18068/files/110(6)_197-202.pdf
application/pdf
1.3 MB
2019-08-08