2024-03-28T16:37:24Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00016488
2022-12-15T03:48:01Z
453:456
471:537:538:1105
透析アミロイドーシスの臨床・病理学的特徴
透析アミロイドーシスの臨床・病理学的特徴
Clinical and Pathological Features of Hemodialysis Associated Amyloidosis
西, 慎一
hemodialysis
amyloidosis
β2-microglobulin
glycoprotein
advanced glycation endproduct
macrophage
血液透析
β2ミクログロブリン
糖蛋白
非酵素的糖化終末産物
マクロファージ
Hemodialysis associated amyloidosis (HA) is a new type systemic amyloidosis. Gejyo elucidated precursor protein of HA was β2-microglobulin (β2-MG), which was a low molecular protein accumulating in the serum of long term hemodialysis patients, in 1985. The histological features of this amyloidosis, which are unique in fiblilar structures and histochemical characters, are clearly different from those of other types of systemic amyloidosis, AL and AA. HA shows specific aspects in clinical features, either. The incidence of various bone and articular complications, such as bone cysts, carpal tunnel syndrome and destructive spondylarthropathy, increases according to the duration of hemodialysis. These complications result from the deposition of amyloid fibrils derived from β2-MG and are suspected to be confirmed in all patients who continue the dialysis treatment more than 10 years. The affinity of amyloid deposition to bone and articular tissues supposed to be an interesting key character in the pathogenic consideration of amyloid fibril formation. We discussed clinical and histological features of HA and summarized the recent studies of pathogenesis about amyloidgenesis including in our research results.
新潟医学会
1998-08
jpn
departmental bulletin paper
http://hdl.handle.net/10191/46031
https://niigata-u.repo.nii.ac.jp/records/16488
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
112
8
443
448
https://niigata-u.repo.nii.ac.jp/record/16488/files/112(8)_443-448.pdf
application/pdf
1.5 MB
2019-08-07