2024-03-29T05:24:14Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00016295
2022-12-15T03:47:53Z
453:456
471:537:538:1102
1)T細胞をめぐるサイトカイン : 最近の話題(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
1)T細胞をめぐるサイトカイン : 最近の話題(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
Regulation of T cell function by cytokines
渡部, 久実
NKT cells
Cytokines
Th1 and Th2 cells
NKT細胞
サイトカイン
Th1とTh2細胞
Many functions of cells of the immune system are mediated through the production of cytokines. CD4+ helper T cells differentiate functionally into one of two subsets, Th1 or Th2. Th1 cells generate IL-2 and IFNγ and support the cellular immune responses. On the other hand, Th2 cells generate IL-4, IL-5 and IL-10 and support the humoral immune responses. A unique population of T cells that carry intermediate levels of TCR exist in the liver and other immune organs. These T cells express IL-2Rβ-chain and receptors of the NK cell lineage. Many investigators call them intTCR cells or NKT cells. Recently, it was demonstrated that NKT cells produce IL-4 and IFN-γ and regulate the differentiation of CD4^+ helper T cells into Th1 or Th2 cells. These findings indicate that NKT cells play an important role of immune regulation by cytokines.
新潟医学会
1998-11
jpn
departmental bulletin paper
http://hdl.handle.net/10191/46332
https://niigata-u.repo.nii.ac.jp/records/16295
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
112
11
667
670
https://niigata-u.repo.nii.ac.jp/record/16295/files/112(11)_667-670.pdf
application/pdf
562.6 kB
2019-08-07