2024-03-29T13:36:14Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00016188
2022-12-15T03:47:46Z
453:456
471:537:538:1099
交感神経・中枢神経の神経ペプチドNPYの遺伝子発現と機能 : 神経分化, 記憶に関わる遺伝子制御
交感神経・中枢神経の神経ペプチドNPYの遺伝子発現と機能 : 神経分化, 記憶に関わる遺伝子制御
Gene Expression and Function of Neuropeptide Y in the Sympathetic Neurons and Central Nervous System-Gene Regulation Involved in Neural Differentiation and Memory.
樋口, 宗史
Gene expression
transcription
transcriptional factor
Neuropeptide Y
enkephalin A
cDNA cloning
neural differentiation
NGF
sympathetic neuron
synaptic plasticity
memory
depolarization
calmodulin
遺伝子発現
転写
転写因子
神経ペプチドY
エンケファリンA
cDNAクローニング
神経分化
神経成長因子
交感神経
シナプス可塑性
記憶
脱分極
カルモジュリン
It is an unsolved question how the neuron-specific genes are . regulated in the mature neurons. The neuronal regulation of neuropeptide Y (NPY) gene which is a cotransmitter of sympathetic neurons and expressed abundantly in the central nervous system. The regulation of this gene resembles that of tyrosine hydroxylase gene.Both the membrane depolarization induced by neural activity and neurotrophic factors such as NGF induced the transcriptiional activation of NPY and enkephalin genes. These mechanisms are due to both Ca/almodulin and MAPK (mitogen-activated protein kinase) dependent processes, respectively. These findings indicated that the transcriptional activations of neural genes are due to the novel transactivational mechanisms. The novel transcriptional factors will be reported.
新潟医学会
1999-02
jpn
departmental bulletin paper
http://hdl.handle.net/10191/46531
https://niigata-u.repo.nii.ac.jp/records/16188
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
113
2
77
82
https://niigata-u.repo.nii.ac.jp/record/16188/files/113(2)_77-82.pdf
application/pdf
1.0 MB
2019-08-07