2024-03-29T07:19:10Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00011558
2022-12-15T04:32:47Z
453:456
471:537:538:1000
1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)
1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)
Genetic study for Alzheimer's disease(Recent Progress in Alzheimer Disease Research)
桑野, 良三
本文データは学協会の許諾に基づきCiNiiから複製したものである
Alzheimer's disease
causative genes
susceptibility genes
genome-wide screening
Alzheimer's disease (AD) is thought to be a multifactorial disease probably caused by complicated interactions between genetic and environmental factors. A rare form of AD exhibits autosomal dominant inheritance of which the most cases can be caused by mutations in three known genes, amyloid precursor protein, pesenilin 1, and prsenilin 2. To date only the APOE-ε4 allele has been universally recognized as a major risk factor for late-onset AD and also as being associated with lowering of the age at onset. However, about 50 % of AD patients do not carry the APOE-ε4 allele. The identification of an additional genetic risk factor (s) would greatly facilitate our understanding of the neuropathological findings, the clinical manifestations and the varying responses to drugs. To search for susceptibility genes for late-onset AD by means of genome-wide screening, the Japanese Genetic Study Consortium for AD (JGSCAD) was organized in 2000, and blood samples were collected. We found that dynamin binding protein gene (DNMBP) on chromosome 10q was significantly associated with AD lacking the ε4 allele, and DNMBP might play a predominant role in the early stage of AD development.
新潟医学会
2007-08
jpn
departmental bulletin paper
http://hdl.handle.net/10191/32761
https://niigata-u.repo.nii.ac.jp/records/11558
http://ci.nii.ac.jp/naid/110007146431
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
121
8
432
437
https://niigata-u.repo.nii.ac.jp/record/11558/files/110007146431.pdf
application/pdf
565.4 kB
2019-08-07