2024-03-29T11:37:33Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00009705
2022-12-15T03:43:40Z
453:456
471:537:538:943
極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性
極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性
Interleukin-6 Polymorphism and Bronchopulmonary Dysplasia Risk in Very Low Birth Weight Infants
臼田, 東平
bronchopulmonary dysplasia
periventricular leukomalacia
gene polymorphism
interleukin-6
very low birth weight infant
Back ground: This study aimed to evaluate the role of interleukin (IL)-6-634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low birth weight infants. Methods: This prospective cohort study included 202 infants (gestational age at birth was 23-34 weeks and birth weight ranged from 500-1499g). Genotypic analysis (polymerase chain reaction-restriction fragment length polymorphism assays) were performed with DNA extracted from whole-blood samples. Results: Genotype distribution (66.8% CC, 28.2% CG, and 5.0% GG) in this study was similar to that in the adult Japanese population. The duration of O_2 therapy in infants with CG/GG genotypes was significantly longer than that in infants with the CC genotype (CG/GG vs. CC: 40.3±52.2 days vs. 28.4±32.6 days, p <0.05). Infants with CG/GG genotypes were more likely to have received postnatal corticosteroid therapy for BPD than those with the CC genotype (CG/GG vs. CC: 20.9% vs. ll.1%, p =0.05). There was no significant difference in the frequency of PVL among IL-6-634 polymorphisms. Conclusions: This study showed an association between IL-6-634 polymorphism and the duration of oxygen therapy for BPD in very low birth weight infants. This finding suggests that the IL-6-634 polymorphism G allele is an aggravating factor of BPD. IL-6-634 polymorphism is not associated with PVL.
新潟医学会
2012-05
jpn
departmental bulletin paper
http://hdl.handle.net/10191/31501
https://niigata-u.repo.nii.ac.jp/records/9705
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
126
5
248
255
https://niigata-u.repo.nii.ac.jp/record/9705/files/126(5)_248-255.pdf
application/pdf
1.1 MB
2019-08-06