2024-03-29T09:25:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006655
2022-12-15T03:39:57Z
453:456
471:537:568:650
The Effects of Methylmercury on the Mitochondrial Energetics of Rat Skeletal Muscle : An in vivo ^<31>P-NMR Study
The Effects of Methylmercury on the Mitochondrial Energetics of Rat Skeletal Muscle : An in vivo ^<31>P-NMR Study
Kuwabara, Takeo
Yuasa, Tatsuhiko
Nagashima, Masaru
Igarashi, Hironaka
Yonemochi, Yousuke
Atsumi, Tetsushi
Miyatake, Tadashi
In this report it showed that methylmercury chrolide (MMC) affected the mitochondrial energetics of rat skeletal muscles in case of chronic intoxication. High energy phosphate compounds were measured by ^<31>P-NMR spectroscopy in the living rat hindleg skeletal muscle. Decreased value of phosphocreatine (PCr)/inorganic phosphate (Pi) ratio was observed in the resting muscle of the MMC intoxicated group, and suspend recovery of the ATP, PCr and intracellular pH after muscle contraction was found in the MMC intoxicated muscle. There was no difference in the ATP levels of the resting muscle between the control and MMC group. These results suggested that the synthesis of ATP was disturbed by the inhibition of mitochondrial respiration below TCA cycle.
Niigata University School of Medicine
1989-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/33536
https://niigata-u.repo.nii.ac.jp/records/6655
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
37
1
45
50
https://niigata-u.repo.nii.ac.jp/record/6655/files/37(1)_45-50.pdf
application/pdf
778.2 kB
2019-08-06