2024-03-28T18:09:06Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006636
2022-12-15T03:39:56Z
453:456
471:537:568:647
Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen
Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen
Senba, Masachika
Kawai, Kioko
Histochemical and immunohistochemical analyses were carried out to determine the relationships of iron accumulation in hepatocellular carcinoma and hepatitis B virus antigens using 300 autopsy cases obtained from Nagasaki University Hospital. Iron accumulation in hepatocellular carcinoma was studied with Prussian blue reaction, and a positive reaction for hepatitis B core antigen and hepatitis B surface antigen were investigated by immunoperoxidase methods. Two cases of iron positive were observed in the cancerous tissue. These cases were hepatitis B core antigen-positive in the cancerous tissue, but hepatitis B surface antigen was negative in the same area. Therefore, hepatocellular carcinoma with hepatitis B surface antigen does not show iron accumulation, whereas the same tumor with hepatitis B core antigen is accompanied by iron accumulation. These findings suggest that hepatitis B core antigen produces the degeneration or collapse of the genes of hepatocellular carcinoma resulting in an iron metabolism disorder.
Niigata University School of Medicine
1990-03
eng
departmental bulletin paper
http://hdl.handle.net/10191/33475
https://niigata-u.repo.nii.ac.jp/records/6636
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
38
1
37
39
https://niigata-u.repo.nii.ac.jp/record/6636/files/38(1)_37-39.pdf
application/pdf
697.7 kB
2019-08-06