2024-03-29T14:30:44Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006631
2022-12-15T03:39:56Z
453:456
471:537:568:646
Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice
Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice
Takagi, Shuko
Yamamoto, Masaharu
Phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid ethylester (MCPA-E) and 2-methyl-4-chlorophenoxybutyric acid ethylester (MCPB-E) were evaluated for subacute toxicity by gavage in male mice. Groups of 10 mice were given daily doses of MCPA-E (50, 100 and 200 mg/kg) or MCPB-E (25, 50 and 100 mg/kg) 5 days/wk for 6 weeks. After completion of the treatment, histopathological changes were noted. In addition to this 6-wk experiment, MCPA-E or MCPB-E was given for 12 weeks, and a comparison was made between the two experiments. The relative liver weight of mice in the group treated with MCPA-E for 6 weeks increased significantly. Histopathological changes were seen in the livers of mice at all dose levels of MCPA-E and MCPB-E, both in the 6 and 12-wk experiments. Hepatic cell atypia and central necrosis were the major findings in mice with hepatomegaly. As for the histology of the gallbladder, no specific change was observed in mice treated with MCPA-E and MCPB-E.
Niigata University School of Medicine
1990-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/33483
https://niigata-u.repo.nii.ac.jp/records/6631
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
38
2
97
101
https://niigata-u.repo.nii.ac.jp/record/6631/files/38(2)_97-101.pdf
application/pdf
750.7 kB
2019-08-06