2024-03-29T10:05:05Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006599
2022-12-15T03:39:55Z
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471:537:568:641
Intraocular Penetration of Norfloxacin Eye Drops
Intraocular Penetration of Norfloxacin Eye Drops
Ooishi, Masao
Miyao, Masuya
Sakaue, Fujio
Tazawa, Hiroshi
Oomomo, Akiko
A 0.3% ophthalmic solution of norfloxacin (NFLX), one of the new quinolone compounds, was instilled into the rabbit eye 5 times every 5 min, and concentrations of NFLX in both cul-de-sac and the ocular tissues were measured. The following were noted: 1. NFLX concentrations exceeding the MIC90 against various bacteria were consistently demonstrated in the cul-de-sac up to 6 h after a single instillation in the normal eye. 2. On 5 instillations every 5 min, high NFLX concentrations were demonstrated in the outer parts of the normal eye. In the inflamed eye, the penetration of NFLX at high concentrations was noted in the outer and inner parts of the eye. 3. In the inflamed eye, the penetrating concentrations were higher than in the normal eye, especially in the aqueous humor, cornea, eyelid, and iris and ciliary body.
Niigata University School of Medicine
1991-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/33439
https://niigata-u.repo.nii.ac.jp/records/6599
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
39
2
67
73
https://niigata-u.repo.nii.ac.jp/record/6599/files/39(2)_67-73.pdf
application/pdf
681.3 kB
2019-08-06