2024-03-29T01:31:40Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006564
2022-12-15T03:39:52Z
453:456
471:537:568:636
Relation between Rheumatoid Arthritis and Alkaline Phosphatase Isoenzymes
Relation between Rheumatoid Arthritis and Alkaline Phosphatase Isoenzymes
Aida, Sumihisa
Serum biliary ALP isoenzyme (ALP_1) was detected in 29.7% of rheumatoid arthritis (RA) patients studied, whereas it was undetectable in osteo-arthrosis patients. The positive activity of ALP_1 in the serum was accompanied by significant but mild increases in γ-GTP and LAP. These findings suggest that RA has an influence on the biliary tract. Furthermore, elevations of ALP_2 , ALP_3 , RAHA, CRP, ESR and IgA as well as a lowering of grip strength, stage and class in the ALP_1-positive RA patients were more marked than in the ALP_1-negative RA patients. These data suggest that the disease activity of RA is higher, and the bone resorption mechanism more enhanced in ALP_1-positive than in ALP_1-negative RA patients. There was no significant relationship between ALP_1 and AMA or ANA. This suggests that the possible overlapping of RA and PBC or SLE could be excluded from the reasons of the detection of ALP_1 activity.
Niigata University School of Medicine
1992-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/33381
https://niigata-u.repo.nii.ac.jp/records/6564
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
40
2
79
83
https://niigata-u.repo.nii.ac.jp/record/6564/files/40(2)_79-83.pdf
application/pdf
667.0 kB
2019-08-06