2024-03-28T23:14:05Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006546
2022-12-15T03:39:53Z
453:456
471:537:568:634
The Frequency of Heterozygous Protein C Deficiency and Heterozygous Protein S Deficiency in Both Normal and Cerebral Thrombotic Conditions
The Frequency of Heterozygous Protein C Deficiency and Heterozygous Protein S Deficiency in Both Normal and Cerebral Thrombotic Conditions
Kobayashi, Isao
Kurihara, Atsushi
Hamaoka, Satomi
Ozawa, Hideyuki
Yazaki, Akihiko
Tamura, Kohji
Amemiya, Norihiko
Endo, Takeshi
Mizoe, Asako
Kume, Shoji
Protein C and protein S activities were assayed in 508 healthy subjects and in 121 patients with cerebral thrombosis, and the frequencies of the congenital deficiencies of these physiological anticoagulant proteins were examined. In the healthy subjects, one case of heterozygous protein C deficiency (type I) and two cases of heterozygous protein S deficiency (type I and type II) were found. The frequencies of heterozygous protein C deficiency and heterozygous protein S deficiency in healthy subjects were 0.19% and 0.38%, respectively. In patients with cerebral thrombosis, one\ncase of heterozygous protein C deficiency (type I) and 8 cases of heterozygous protein S deficiency (type I, 3; type II, 3; type III, 2) were found. The frequencies of heterozygous protein C deficiency and heterozygous protein S deficiency in cerebral thrombosis were 0.8% and 6.4%, respectively. In cerebral thrombosis the frequency of heterozygous protein S deficiency was higher than that of heterozygous protein C deficiency; heterozygous protein S deficiency seems to be a risk factor for the later onset of cerebral thrombosis.
Niigata University School of Medicine
1992-12
eng
departmental bulletin paper
http://hdl.handle.net/10191/33390
https://niigata-u.repo.nii.ac.jp/records/6546
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
40
4
137
144
https://niigata-u.repo.nii.ac.jp/record/6546/files/40(4)_137-144.pdf
application/pdf
1.2 MB
2019-08-06