2024-03-28T20:33:27Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006494
2022-12-15T03:39:50Z
453:456
471:537:568:626
Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats
Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats
Nakatsuji, Tadako
Iron-related autoimmune disturbances were studied in male amd female Lewis rats. Among 16 males injected with Wister rat liver ferritin, one injected with only the ferritin showed non-hemolytic autoimmune disturbances. A 49 g weight loss, 9.7% siderocytes, high titer anti-nuclear antibody to hepatic nucleus (92%) and low titer auto-red blood cell (RBC) antibody were recognized in this rat. Another male was diagnosed with autoimmune hemolytic anemia after treatment with both the ferritin and anti-Ia monoclonal antibody (mAb) to major histocompatibility complex (MHC) class II, Ia antigen. Auto-RBC antibody was identified in this animal. Mildly or moderately disturbed self-recognitions were found in 5 males treated with ferritin and anti-Ia mAb. On the other hand, all 15 females showed weaker autoimmunity than the males in the same experimental systems. Females differed from males in two points: First, increased iron depositions in proximal convoluted renal tubules were observed in all females injected with the ferritin, especially in one of the females treated together with anti-IA (MHC class I) mAb. Second, atrophic medullae with a relatively hyperplastic cortex were shown in the adrenal glands of 3 females. Among 11 previously pregnant females, 6 had the same atrophic medullae. These data suggested the following two conclusions: 1) Disturbed iron incorporation in mitochondria is an important trigger of pre-autoimmune hemolysis in male rats; 2) In female rats, the adrenal and renal tubule axis reacts to improve self-recognition based on immunohemopoietic actions.
Niigata University School of Medicine
1994-09
eng
departmental bulletin paper
http://hdl.handle.net/10191/33246
https://niigata-u.repo.nii.ac.jp/records/6494
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
42
3
103
107
https://niigata-u.repo.nii.ac.jp/record/6494/files/42(3)_103-107.pdf
application/pdf
608.2 kB
2019-08-06