2024-03-29T13:59:46Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006455
2022-12-15T03:39:45Z
453:456
471:537:568:621
Immunological Effects of Lumin-A, a Fluorescent Antioxidant Drug, on T Cell Subsets in Various Immune Organs of Mice
Immunological Effects of Lumin-A, a Fluorescent Antioxidant Drug, on T Cell Subsets in Various Immune Organs of Mice
Ohtsuka, Kazuo
Yamamura, Soichiro
Osman, Yasser
Arai, Katsumitsu
Hasegawa, Katsuhiko
Yamagiwa, Satoshi
Nakayama, Mauro
Abo, Toru
lumin-A
antioxidant drug
extrathymic T cell
thymus-derived T cell
It is important to determine how fluorescent antioxidant drugs act as immunomodulators. Since a new T-cell population, namely, extrathymic T cells, has recently been identified in the liver and other immune organs, our attention was focused on how one of the above-mentioned drugs (Lumin-A in this study) affects the distribution of extrathymic T cells and thymus-derived T cells in various immune organs. When Lumin-A was administered into mice daily (10 μg/mouse/day) with intraperitoneal or oral route for 3 wks, its unique effect was observed, depending on the routes. Especially, the oral ad libitum administration of Lumin-A induced a prominent induction of thymus-derived T cells, but not extrathymic T cells, in the peripheral immune organs, the spleen and the liver. The present results suggest that a fluorescent antioxidant drug, Lumin-A, has an ability to induce the thymus-derived T cells, i.e., usual T cells for processing foreign antigens, into the periphery.
Niigata University School of Medicine
1995-12
eng
departmental bulletin paper
http://hdl.handle.net/10191/33218
https://niigata-u.repo.nii.ac.jp/records/6455
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
43
4
205
209
https://niigata-u.repo.nii.ac.jp/record/6455/files/43(4)_205-209.pdf
application/pdf
557.3 kB
2019-08-06