2024-03-29T07:07:58Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006407
2022-12-15T03:39:41Z
453:456
471:537:568:615
Portal Injection of Dopamine Directly Increases Portal Venous Blood Flow in 66 Percent Hepatectomized Rats
Portal Injection of Dopamine Directly Increases Portal Venous Blood Flow in 66 Percent Hepatectomized Rats
Nishimura, Atsushi
Fujita, Nobuhiro
Sakaguchi, Takeo
Aono, Takashi
Tsukada, Kazuhiro
Hatakeyama, Katsuyoshi
hepatic blood flow
hepatectomy
liver
Portal venous blood flow (PVF) and systemic arterial pressure (SAP) were examined after dopamine (DA) injection into the portal or femoral vein in 66 percent hepatectomized rats. The portal injection of DA at 25 μg/kg/min evoked an increase in PVF without any change in SAP. PVF response due to portal DA injection tended to be dose dependent, and when portal venous resistance was defined as portal venous pressure/PVF, the resistance was reduced concomitant with an increase in PVF. The same dosage of DA injected into the femoral vein increased PVF with an increase in SAP. These results suggest that DA directly contributes to the PVF control under a hepatectomized condition, and that DA receptor in the portal vasculature is involved in this response.
Niigata University School of Medicine
1997-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/33123
https://niigata-u.repo.nii.ac.jp/records/6407
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
45
2
75
79
https://niigata-u.repo.nii.ac.jp/record/6407/files/45(2)_75-79.pdf
application/pdf
567.9 kB
2019-08-06