2024-03-28T12:18:41Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006390
2022-12-15T03:39:42Z
453:456
471:537:568:613
Orally Administered Ginseng Extract Stimulates Liver Regeneration in Partially Hepatectomized Rats
Orally Administered Ginseng Extract Stimulates Liver Regeneration in Partially Hepatectomized Rats
Cui, Xing
saponin
liver resection
hepatocyte proliferation
rat
The effects of the oral administration of ginseng extract (GE, the root of panax ginseng C. A. Meyer) and its constituents (GRG, ginsenoside-Rg_1 and GRB, ginsenoside-Rbl_1) on liver regeneration were examined in 66% hepatectmized rats. When liver regeneration was evaluated by the mitotic index of the hepatocyte (MI), a significant increase in the MI was observed 2 and 3 days after GE administration, and the MI response was dose-dependent. Food intake was not affected by GE administration, nor there was any change in the serum insulin concentration. It was also noted that the oral administration of GRG produced a MI response similar to that caused by GE administration. Serum parameters indicating liver and kidney function were unchanged after GE administration. These observations lead us to conclude that orally administered GE and its specific constituent are capable of stimulating liver regeneration without serious systemic effects.
Niigata University School of Medicine
1997-12
eng
departmental bulletin paper
http://hdl.handle.net/10191/33136
https://niigata-u.repo.nii.ac.jp/records/6390
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
45
4
161
166
https://niigata-u.repo.nii.ac.jp/record/6390/files/45(4)_161-166.pdf
application/pdf
1.7 MB
2019-08-06