2024-03-28T20:15:22Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006370
2022-12-15T03:39:40Z
453:456
471:537:568:610
Plasma Indocyanine Green Disappearance Induced by Electrical Stimulation of the Hepatic Vagal Branch in Rats
Plasma Indocyanine Green Disappearance Induced by Electrical Stimulation of the Hepatic Vagal Branch in Rats
Sakaguchi, Takeo
Nishimura, Atsushi
Cui, Xing
Aono, Takashi
anion transport
hepatic dye metabolism
liver
rat
The plasma disappearance curve of indocyanine green (ICG) was estimated for 15 min by a non-invasive serial monitoring system following electrical stimulation of the hepatic vagal branch in anesthetized rats. The stimulation parameters were 6 V, 1 ms width (square wave for 6 min) and 10 Hz. When ICG 0.25 mg/kg (200 μl) was injected into the jugular vein as a bolus, the curve for ICG was obtained; this was shifted downwards by the electrical stimulation of the hepatic vagal branch. The magnitude of ICG response due to stimulation tended to be frequency dependent. No appreciable change in systemic arterial pressure or portal venous blood flow was seen during the ICG estimation. These results suggest that the hepatic vagal branch contains signals which directly modify the uptake of ICG by the hepatocytes without hepatic circulatory influence.
Niigata University School of Medicine
1998-09
eng
departmental bulletin paper
http://hdl.handle.net/10191/33085
https://niigata-u.repo.nii.ac.jp/records/6370
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
46
3
89
92
https://niigata-u.repo.nii.ac.jp/record/6370/files/46(3)_89-92.pdf
application/pdf
476.5 kB
2019-08-06