2024-03-28T23:33:59Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006359
2022-12-15T03:39:40Z
453:456
471:537:568:608
Platelet and Cholesterol Responses Caused by Oral Administration of Ginseng Extract in 66% Hepatectomized Rats
Platelet and Cholesterol Responses Caused by Oral Administration of Ginseng Extract in 66% Hepatectomized Rats
CUI, Xing
SAKAGUCHI, Takeo
OHTAKE, Masahiro
SHIRAI, Yoshio
HATAKEYAMA, Katsuyoshi
major abdominal surgery
hepatic resection
ginseng delivery
platelet
cholesterol
postoperative complications
Platelet counts and serum cholesterol levels in the blood were examined after oral administration of ginseng extract (GE) to 66% hepatectomized rats. A significant decrease in the platelet count (PC) and adhesiveness (PA) was obtained 3 days after hepatectomy when GE 125 mg/kg/day was administered, and the PA reduction was dose dependent in the range of 0-250 mg/kg/day. The serum concentration of total cholesterol was also decreased by the GE administration, but food intake was unaffected. Serum parameters indicating liver and kidney functions were unchanged after GE administration except for lipid metabolic parameters. Because enhanced PC and PA in the presence of hypercholesterolemia are apt to lead to thromboembolism after major abdominal surgery, these results suggest that orally administered GE is capable of preventing the thromboembolic tendency associated with major hepatic surgery.
Niigata University School of Medicine
1999-03
eng
departmental bulletin paper
http://hdl.handle.net/10191/1870
https://niigata-u.repo.nii.ac.jp/records/6359
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
47
1
15
19
https://niigata-u.repo.nii.ac.jp/record/6359/files/KJ00000007195.pdf
application/pdf
768.0 kB
2019-08-06