2024-03-28T18:11:34Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006267
2022-12-15T03:39:36Z
453:456
471:537:568:592
The Preventive Effect of β-blockers, Carvedilol and Metoprolol, on Mental Stress-induced Changes in Cardiovascular Functions by a Color Word Conflict Test
The Preventive Effect of β-blockers, Carvedilol and Metoprolol, on Mental Stress-induced Changes in Cardiovascular Functions by a Color Word Conflict Test
WATANABE, Yasuo
OKADA, Masayoshi
TSURUMAKI, Tatsuru
GEJYO, Fumitake
HIGUCHI, Hiroshi
metoprolol
carvedilol
mental stress
color word conflict test
β-blocker
heart rate
blood pressure
Experimental mental stress by a computerized color word conflict test was developed. The effects of a single oral administration of two different β-blockers, carvedilol (a vasodilating β-/α_1-blocker, 20 mg) and metoprolol (a β_1-selective blocker, 20 mg), on a color word conflict test (mental stress)-induced increase in heart rate and systolic blood pressure were investigated in 108 healthy volunteers, 21-24 years of age, by double blind protocol. At rest carvedilol and metoprolol gradually reduced the heart rate, and slightly lowered systolic and diastolic blood pressure. The mental stress by the color word conflict test significantly increased the heart rate and systolic blood pressure by a respective 3.1±0.6/min and 2.0±0.9mmHg. Carvedilol completely inhibited the mental stress-induced increases in both systolic blood pressure and heart rate 3 h after administration, and metoprolol significantly blocked the increase in systolic blood pressure. These findings indicated that β-blockers effectively prevent mental stress-induced changes in cardiovascular functions.
Niigata University School of Medicine
2003-06
eng
departmental bulletin paper
http://hdl.handle.net/10191/1887
https://niigata-u.repo.nii.ac.jp/records/6267
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
51
2
43
48
https://niigata-u.repo.nii.ac.jp/record/6267/files/KJ00000007364.pdf
application/pdf
4.2 MB
2019-08-06