2024-03-29T09:40:53Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006260
2022-12-15T03:39:37Z
453:456
471:537:568:590
A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)
A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)
TAKIZAWA, Yoko
SHIMIZU, Takao
IWAYA, Akira
HATAKEYAMA, Katsuyoshi
TANEIKE, Ikue
NAKAGAWA, Saori
NYUZUKI, Satoru
GONDAIRA, Fumio
TSUKADA, Hiroki
GEJYO, Fumitake
YAMAMOTO, Tatsuo
methicillin-resistant Staphylococcus aureus (MRSA)
multiple superantigenic toxin (MST)
toxic shock syndrome (TSS)
risk factor
Methicillin-resistant Staphylococcus aureus (MRSA), an important cause of nosocomial infections, produces a number of superantigenic toxins such as toxic shock syndrome toxin (TSST)-1 and staphylococcal enterotoxin (SE) C in many cases. However, toxic shock syndrome (TSS) only rarely occurs in MRSA infections. In this study, we isolated MRSA strains from the stool and sputum of a patient with TSS and characterized the molecular nature of the TSS-associated MRSA strains. The two MRSA strains were indistinguishable from each other, as demonstrated by pulsed-field gel electrophoresis. The coagulase type was type 2. The two MRSA strains manifested a multiple superantigenic toxin (MST) pattern of TSST-1, SEA, SEC, SEG, SEH, SEI, and SET in the PCR assay, unlike the previously characterized MRSA strains that lacked (e. g.) SEA. When human peripheral blood mononuclear cells were stimulated with superantigenic toxins, a combination of TSST-1, SEA, and SEC induced much higher levels of cytokine production than did the individual toxin or combination of (e. g.) TSST-1 and SEC. The data suggest that the MST pattern of MRSA could be a risk factor in the development of TSS.
Niigata University School of Medicine
2003-12
eng
departmental bulletin paper
http://hdl.handle.net/10191/1850
https://niigata-u.repo.nii.ac.jp/records/6260
AA00508361
05677734
Acta medica et biologica
Acta medica et biologica
51
4
141
147
https://niigata-u.repo.nii.ac.jp/record/6260/files/KJ00004267697.pdf
application/pdf
2.1 MB
2019-08-06