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Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats ラット上喉頭神経電気刺激中における嚥下頻度の変化 Tsuji, Kojun Copyright (C) 2014 Elsevier Swallowing Superior laryngeal nerve Rat Central pattern generator Nucleus tractus solitarii The aim of the present study was to investigate the adaptation of the swallowing reflex in terms of reduced swallowing reflex initiation following continuous superior laryngeal nerve stimulation. Forty-four male Sprague Dawley rats were anesthetized with urethane. To identify swallowing, electromyographic activity of the left mylohyoid and thyrohyoid muscles was recorded. To evoke the swallowing response, the superior laryngeal nerve (SLN), recurrent laryngeal nerve, or cortical swallowing area was electrically stimulated. Repetitive swallowing evoked by continuous SLN stimulation was gradually reduced, and this reduction was dependent on the resting time duration between stimulations. Prior SLN stimulation also suppressed subsequent swallowing initiation. The reduction in evoked swallows induced by recurrent laryngeal nerve or cortical swallowing area stimulation was less than that following superior laryngeal nerve stimulation. Decerebration had no effect on the reduction in evoked swallows. Prior subthreshold stimulation reduced subsequent initiation of swallowing, suggesting that there was no relationship between swallowing movement evoked by prior stimulation and the subsequent reduction in swallowing initiation. Overall, these data suggest that reduced sensory afferent nerve firing and/or trans-synaptic responses, as well as part of the brainstem central pattern generator, are involved in adaptation of the swallowing reflex following continuous stimulation of swallow-inducing peripheral nerves and cortical areas. 学位の種類: 博士（歯学）. 報告番号: 甲第4015号. 学位記番号: 新大院博（歯）甲第328号. 学位授与年月日: 平成27年3月23日 Brain Research Bulletin. 2015, 111, 53-61. 新大院博（歯）甲第328号 新潟大学 2015-03-23 eng thesis http://hdl.handle.net/10191/32184 https://niigata-u.repo.nii.ac.jp/records/5607 info:doi/10.1016/j.brainresbull.2014.12.008 13101甲第4015号 博士（歯学） 2015-03-23 新潟大学 https://niigata-u.repo.nii.ac.jp/record/5607/files/h26ndk328.pdf application/pdf 976.2 kB 2019-08-05 https://niigata-u.repo.nii.ac.jp/record/5607/files/h26ndk328_a.pdf application/pdf 200.1 kB 2019-08-05