2024-03-29T13:43:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00002643
2022-12-15T03:35:52Z
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Factors Affecting Short-Term Mortality in Very Low Birth Weight Infants in Japan
Oshiki, Rieko
Nakamuara, Kazutoshi
Yamazaki, Akira
Sakano, Chuji
Nagayama, Yoshihisa
Ooishi, Masanori
Yamamoto, Masaharu
very low birth weight infant(VLBWI)
mortality
birth weight
risk factor
historical cohort study
No epidemiological surveys have examined risk factors related to the death of very low birth weight infants (VLBWIs) in Japan. The objectives of this study were to examine the death rate and fatalities related to complications among VLBWIs, and to analyze factors possibly determining the death of VLBWIs. The subjects of this study were 811 VLBWIs admitted to the Neonatal Care Center of Niigata City General Hospital between April 1987 and March 2003. We obtained information on gender, birth weight, gestational age, Apgar scores, single/multiple pregnancy, postnatal transfer, mode of delivery, complications and outcome (alive or deceased) at the time of discharge from medical records. Of the 811 infants, 98 died prior to discharge (12.1%). Logistic regression analysis showed that independent risk factors for death of VLBWIs were male gender (relative risk [RR]: 2.0), low birth weight (RR: 0.56), necrotizing enterocolitis (RR: 58.0), pulmonary hypoplasia (RR: 37.8), chromosomal abnormalities (RR: 36.3), congenital heart diseases (RR: 9.8), persistent fetal circulation (RR: 9.6), neonatal asphyxia (RR: 6.3) and sepsis (RR: 4.4). The risk for death rises 1.8-fold if birth weight decreases by 100 g. A very high risk of perinatal death is associated with necrotizing enterocolitis, pulmonary hypoplasia or chromosomal abnormalities. The risk of death due to congenital heart diseases or neonatal asphyxia is relatively lower, but the incidences of these two disorders are high (8% and 6%, respectively). From the viewpoint of prophylactic treatment aimed at reducing the death rate of VLBWIs, measures to increase birth weight are of primary importance. Furthermore, early treatment and improved perinatal management of congenital heart diseases and neonatal asphyxia are anticipated to reduce the overall death rate of VLBWIs.
Tohoku University Medical Press
2005-02
eng
journal article
VoR
http://hdl.handle.net/10191/4933
https://niigata-u.repo.nii.ac.jp/records/2643
http://doi.org/10.1620/tjem.205.141
AA00863920
0040-8727
Tohoku Journal of Experimental Medicine
205
2
141
150
https://niigata-u.repo.nii.ac.jp/record/2643/files/tohoku j.exp.med.205(2).pdf
application/pdf
462.8 kB
2019-07-29