2024-03-29T07:29:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00002229
2022-12-15T03:35:04Z
423:424:425
453:454
Twin-pair rete ridge analysis : a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa
Twin-pair rete ridge analysis : a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa
Sami, Mustafa M.
Saito, Masahisa
Muramatsu, Shogo
Mikami, Toshihiko
Al-Eryani, Kamal
Sawair, Faleh A.
Eid, Rasha Abu
Cheng, Jun
Kikuchi, Hisakazu
Saku, Takashi
borderline malignancies
image analysis
oral mucosa
rete ridges
twin pairs
Epithelial dysplasia and carcinoma in-situ (CIS) of the oral mucosa are two different borderline grades similar to each other, and it is difficult for pathologists to distinguish these two lesions on hematoxylin and eosin-stained sections only. To support objective differential diagnoses, we have developed a new computer-aided analysis system. The method was based on a comparison of the elevation levels in the drop shape between twin-pairs of neighboring rete ridges. The dissimilarity of the drop shape was defined by the roundness difference between a pair of rete ridge units. All the steps were performed using a graphical user interface. The similarity levels in epithelial dysplasia were higher than those in CIS, whose histopathological diagnoses were conventionally made by experienced pathologists. The developed image processing method showed good promise for the computer-aided pathological assessment of oral borderline malignancies in clinical practice.
Japanese Society for Oral Pathology
2010
eng
journal article
http://hdl.handle.net/10191/22263
https://niigata-u.repo.nii.ac.jp/records/2229
info:doi/10.3353/omp.14.89
AA11097826
13420984
Oral medicine & pathology
Oral medicine & pathology
14
3
89
97
https://niigata-u.repo.nii.ac.jp/record/2229/files/14_3_89-97.pdf
application/pdf
729.0 kB
2019-07-29