WEKO3
アイテム
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5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会)
http://hdl.handle.net/10191/35434
http://hdl.handle.net/10191/354349ad5aaf2-5e33-46ca-9180-bc5dc90de5f6
名前 / ファイル | ライセンス | アクション |
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126(11)_589-592.pdf (620.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-12-11 | |||||
タイトル | ||||||
タイトル | 5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atherosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic kidney disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensin II receptor antagonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroxisome proliferator activated receptor γ agonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Mechanisms and Therapeutic Options for Atherosclerosis | |||||
著者 |
山本, 卓
× 山本, 卓× 丸山, 弘樹× 風間, 順一郎× 成田, 一衛 |
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著者別名 | ||||||
識別子 | 65807 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yamamoto, Suguru | |||||
著者別名 | ||||||
識別子 | 65808 | |||||
識別子Scheme | WEKO | |||||
姓名 | Maruyama, Hiroki | |||||
著者別名 | ||||||
識別子 | 65809 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kazama, Junichiro | |||||
著者別名 | ||||||
識別子 | 65810 | |||||
識別子Scheme | WEKO | |||||
姓名 | Narita, Ichiei | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cardiovascular disease is dramatically increased across the entire spectrum of patients with chronic kidney disease. Angiotensin II has a role in renal damage-induced acceleration of atherosclerosis with hypertension in apolipoprotein E deficient (apoe-/-) mice. Losartan, an AII receptor antagonist (ARB), reduces uninephrectomy (UNx)-induced acceleration of atherosclerosis in apoe-/- mice. Losartan also modurates macrophage chemotaxis, cholesterol efflux and inflammation in vitro. We examined if peroxisome proliferator activated receptor γ (PPAR γ) agonist benefits UNx-induced acceleration of atherosclerosis and the possibility of a synergistic interaction with ARB. UNx mice were treated with pioglitazone (a PPAR γ agonist), losartan (an ARB), or both. UNx significantly increased atherosclerosis in proximal aorta which was lessened by pioglitazon and losartan, but especially by the combination which was significantly less than pioglitazone or losartan alone. Assessment of the plaque lesions revealed significantly less necrotic plaque area in the lesion with pioglitazon and losartan treatment. Notably, the macrophage area of combination treatment with pioglitazon and losartan had lesser number of pro-inflammatory M1 phenotype and greater number of alternatively anti-inflammatory M2 phenotype. Those results suggest that ARB especially together with PPAR γ agonist modurates macrophage functions in renal-injury-induced acceleration of atherosclerotic lesion. Therapeutic interventions for hypertension should be considered to modulate progressive atherosclerosis, especially macrophage function. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 126, 号 11, p. 589-592, 発行日 2012-11 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |