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Regional Cerebral Blood Flow in Parkinson's Disease Measured with N-isopropyl-p-[^<123>I]iodoamphetamine (IMP) SPECT
http://hdl.handle.net/10191/33386
http://hdl.handle.net/10191/3338640628d99-7f3c-4eb7-83b2-4f06ffec605d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
40(3)_115-121.pdf (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-18 | |||||
| タイトル | ||||||
| タイトル | Regional Cerebral Blood Flow in Parkinson's Disease Measured with N-isopropyl-p-[^<123>I]iodoamphetamine (IMP) SPECT | |||||
| タイトル | ||||||
| タイトル | Regional Cerebral Blood Flow in Parkinson's Disease Measured with N-isopropyl-p-[^<123>I]iodoamphetamine (IMP) SPECT | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Odano, Ikuo
× Odano, Ikuo× Nishihara, Mamiko× Ishikawa, Atsushi× Hayashi, Hiroko× Higuchi, Shoichi× Ibayashi, Katsuhiko× Sakai, Kunio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | N -isopropyl-p- [ ^<123>I] iodoamphetamine (IMP) SPECT studies were performed on 21 patients (13 females; 45-73 yrs) with idiopathic Parkinson's disease (PD) and 10 age-matched normal controls (39-69 yrs). Regional Cerebral Blood Flow (rCBF) was quantitatively measured by the arterial blood sampling method. When compared with normal controls, global CBF, and rCBF in the frontal cortex and in the basal ganglia were reduced 22.1% (p<0.0l), 25.0% (p<0.05) and 25.6% (p<0.01), respectively. The reduction of rCBF in the basal ganglia was significantly correlated (p <0.05) with symptoms such as gait disturbance, frozen gait and motor disability score. However, no significant correlation was observed between the severity of dementia and any regional reduction of CBF, including the frontal or parietal cortices. These data show that the severity of dementia in PD may be related to other factors but not with CBF. Quantification of rCBF with ^<123>I-IMP SPECT imaging is useful\nfor evaluation and follow-up patients with PD. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 40, 号 3, p. 115-121, 発行日 1992-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
