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Alterations in Cardiac β-Adrenoceptors During the Development of Rat Experimental Autoimmune Myocarditis
http://hdl.handle.net/10191/1872
http://hdl.handle.net/10191/18723413bf50-0eaa-4a3d-bda3-32b42ecefe7e
名前 / ファイル | ライセンス | アクション |
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KJ00000007251.pdf (3.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Alterations in Cardiac β-Adrenoceptors During the Development of Rat Experimental Autoimmune Myocarditis | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Alterations in Cardiac β-Adrenoceptors During the Development of Rat Experimental Autoimmune Myocarditis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat experimental autoimmune myocarditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac muscle β-adrenoceptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ^3H-CGP12177 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radioligand binding assay | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
SUZUKI, Ayako
× SUZUKI, Ayako× NAKAMURA, Takashi× OHNUKI, Toshio× HIRONO, Satoru× AIZAWA, Yoshifusa× WATANABE, Kenichi× NAGATOMO, Takafumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we investigated changes in cardiac β-adrenoceptor densities (Bmax) and affinities (dissociation constant : Kd) by Scachard analysis using the radioligand binding assay method during the development of rat experimental autoimmune myocarditis (EAM). Rats at 11 weeks of age were subcutaneously injected in both foodpads with 0.2ml of antigen-adjuvant emulsion for the induction of EAM. A peak increase in Bmax values of cardiac muscles of EAM was observed at day 18 (active phase), followed by a tendency to decrease until day 214 after immunization. However, there were no changes in Kd values at any stage of EAM. Thus, the present study indicates that β-AR densities change according to the stages of EAM. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 2, p. 51-54, 発行日 2000-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |