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Proinflammatory Cytokines Correlate with the Development of Encephalopathy in Patients with Fulminant Hepatitis
http://hdl.handle.net/10191/1833
http://hdl.handle.net/10191/1833939d34d3-4b07-4335-90a2-b1c783bacc3f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161689.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Proinflammatory Cytokines Correlate with the Development of Encephalopathy in Patients with Fulminant Hepatitis | |||||
| タイトル | ||||||
| タイトル | Proinflammatory Cytokines Correlate with the Development of Encephalopathy in Patients with Fulminant Hepatitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | proinflammatory cytokines | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | encephalopathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intracranial pressure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fulminant hepatitis | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
HIDA, Seiji
× HIDA, Seiji× HIRASAWA, Hiroyuki× ODA, Shigeto× MATSUDA, Kenichi× ENDOH, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Proinflammatory cytokines are thought to play important roles in the pathophysiology of encephalopathy in patients with fulminant hepatitis (FH). The aim of this study was to investigate the association between circulating proinflammatory cytokines and the severity of encephalopathy in FH patients. The study included 19 patients with FH who were treated in an intensive care unit (ICU) at Chiba University Hospital over the past 7 years. The patients were divided into three groups according to changing patterns of grades of hepatic encephalopathy during their ICU stay : those showing no deterioration of encephalopathy (ND group, n=6), those experiencing recovery and deterioration of encephalopathy (RD group, n=7), and those exhibiting progressive deterioration of encephalopathy (PD group, n = 6). Concentrations of circulating IL-1β, TNF-α, and IL-6, and ammonia were daily measured in the 3 groups. In serial measurements during the 1st week of ICU stay, serum concentrations of IL-6 were at significantly higher levels in PD group as compared with other two groups (both p<0.01) from the 5th ICU day to the 7th ICU day. In the RD group, serum concentrations of TNF-α and IL-6 were significantly higher during the period of redevelopment of encephalopathy as compared with the recovery period (both p<0.05). There was a significant relationship between serum TNF-α and IL-6 concentration as well as intracranial pressure (r=0.290, p<0.01 and r=0.516, p<0.01, respectively). In conclusion, TNF-α and IL-6, but not IL-1β, are implicated in the development of FH-related encephalopathy presumably by inducing intracranial hypertension. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 4, p. 141-148, 発行日 2004-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
HIDA, Seiji, HIRASAWA, Hiroyuki, ODA, Shigeto, MATSUDA, Kenichi, ENDOH, Hiroshi, 2004, Proinflammatory Cytokines Correlate with the Development of Encephalopathy in Patients with Fulminant Hepatitis: Niigata University School of Medicine, 141–148 p.
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