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High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer
http://hdl.handle.net/10191/30973
http://hdl.handle.net/10191/30973236f91e8-66be-4c38-aecc-c173ae05ec28
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本文 (298.4 kB)
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要旨 (170.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2014-12-09 | |||||
| タイトル | ||||||
| タイトル | High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer | |||||
| タイトル | ||||||
| タイトル | High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gallbladder cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genetic alteration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TP53 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | K-ras | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bolivia | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | ボリビア胆嚢がん患者におけるTP53遺伝子およびK-ras遺伝子の変異頻度 | |||||
| 著者 |
Asai, Takao
× Asai, Takao |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50407 | |||||
| 姓名 | 浅井, 孝夫 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from the cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exon 5 to 8 and K-ras mutations at codons 12, 13, and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had the TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had the K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three of these mutations were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第3945号. 学位記番号: 新大院博（医）甲第612号.学位授与年月日: 平成26年9月22日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Asian Pacific Journal of Cancer Prevention. 2014, 15(13), 5449-5454. | |||||
| 書誌情報 | p. 1-19, 発行日 2014-09-22 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.7314/APJCP.2014.15.13.5449 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2014-09-22 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第3945号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第612号 | |||||
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Cite as
Asai, Takao, 2014, High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer: 新潟大学, p. 1–19.
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