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Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice
http://hdl.handle.net/10191/13103
http://hdl.handle.net/10191/1310361b23604-9e36-4acd-a68d-9f453775bc6b
名前 / ファイル | ライセンス | アクション |
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62(2)_117-123.pdf (868.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-07-14 | |||||
タイトル | ||||||
タイトル | Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-aminobutyric acid (GABA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Th1/Th2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-アミノ酪酸(GABA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ヒスタミン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Th1/Th2 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | オバルブミン感作したBALB/c マウスに対するγ- アミノ酪酸(GABA)の血清IgE レベル抑制作用 | |||||
著者 |
Hori, Ayumi
× Hori, Ayumi× Hara, Takashi× Saito, Kana× Joh, Toshio |
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著者別名 | ||||||
識別子 | 163214 | |||||
識別子Scheme | WEKO | |||||
姓名 | 堀, あゆみ | |||||
著者別名 | ||||||
識別子 | 163215 | |||||
識別子Scheme | WEKO | |||||
姓名 | 原, 崇 | |||||
著者別名 | ||||||
識別子 | 163216 | |||||
識別子Scheme | WEKO | |||||
姓名 | 佐藤, 可奈 | |||||
著者別名 | ||||||
識別子 | 163217 | |||||
識別子Scheme | WEKO | |||||
姓名 | 城, 斗志夫 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | γ-aminobutyric acid (GABA) is a kind of amino acid and has been received much attention for their biological activities. In the present study, we examined the influence of GABA on immunomodulatory activities and serum IgE levels, employing ovalbumin (OVA)-immunized BALB/c mice. In cytokine production assay in vitro, GABA showed increased IFN-γ production concomitant with decreased IL-4 production by splenocytes from OVA-immunized BALB/c mice. When administrated orally, GABA was effective for decreasing both total and OVA-specific IgE levels in serum. In addition, these decreased IgE levels by administrated GABA were paralleled with increased IFN-γ production and decreased IL-4 production in splenocytes ex vivo. It seems that GABA can potentially suppress Th2 responses including IL-4 production via promoting Th1-skewed response in vivo, leading to down-regulation of IgE synthesis. These results suggest that GABA might be useful for preventing IgE-mediated allergic diseases. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | γ-アミノ酪酸(GABA)は,食品に含まれる機能性成分として注目されている。本研究では,オバルブミン(OVA)感作したBALB/cマウスに対するGABAの免疫制御活性について調べ,経口投与による血清IgEレベルの抑制作用について検討した。in vitro培養試験において,GABAはマウス脾細胞のインターフェロン-γ(IFN-γ)の産生を促進すると同時にインターロイキン-4(IL-4)の産生を抑制した。GABAを経口投与した結果,OVA感作BALB/cマウスにおける総IgE及びOVA特異的IgEの血清レベルが有意に低下した。さらに,ex vivo培養試験において,GABAを経口投与したマウスの脾細胞ではOVA誘導性のIFN-γ産生促進とIL-4産生抑制が認められた。GABAは,Th1の誘導を介してIL-4産生を始めとしたTh2応答を抑制し,IgE産生を抑制する可能性がある。以上の結果から,GABAはIgEが関与するアレルギー疾患の予防に有用であることが示唆される。 | |||||
書誌情報 |
新潟大学農学部研究報告 en : 新潟大学農学部研究報告 巻 62, 号 2, p. 117-123, 発行日 2010-03 |
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出版者 | ||||||
出版者 | 新潟大学農学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03858634 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00183393 | |||||
著者版フラグ | ||||||
値 | publisher |