WEKO3
アイテム
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抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析
http://hdl.handle.net/10191/36481
http://hdl.handle.net/10191/3648186344d52-3cb0-4105-89da-4cea4cd5e26f
名前 / ファイル | ライセンス | アクション |
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101(6)_382-389.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-01-07 | |||||
タイトル | ||||||
タイトル | 抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monoclonal antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelin-associated glycoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mononuclear cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | surface marker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | モノクローナル抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ミエリン糖蛋白 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | リンパ球 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 表面抗原 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Characterization of the surface antigens on human mononuclear cells to which anti-myelin associated glycoprotein (MAG) monoclonal antibodies bind | |||||
著者 |
荒井, 元美
× 荒井, 元美 |
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著者別名 | ||||||
識別子 | 144533 | |||||
識別子Scheme | WEKO | |||||
姓名 | Arai, Motomi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Three (GC-J4, MC-P2 and MC-P4) out of five murine monoclonal antibodies (mAbs) to myelin-associated glycoprotein (MAG) bound to human mononuclear cells (MNC). The results of the competitive inhibition assay suggested that MC-P2 and MC-P4 bind directly to or close to the Leu 7 epitope, and that GC-J4 binds to the epitope which is distinct from the Leu 7 epitope. The electrophoretic patterns of immunoprecipitates with GC-J4, MC-P2 and anti-Leu 7 from detergent lysates of surface labeled human MNC were very similar. The target molecules of anti-Leu 7, MC-P2 and GC-J4 have apparent molecular weights of 205, 170, 150, 135, 110, 85, 65 and 55 kDa, and they are monomeric or noncovalently associated proteins. The patterns of immunoprecipitates with MC-P4 were slightly different from those with anti-Leu 7 and MC-P2. The implications of these results are as follows: 1) The mAb with specificity to the carbohydrate part of MAG reacts with the Leu 7-reactive molecule on human MNC. 2) At least two epitopes detected by anti-MAG mAbs coexist on the surface molecules with various apparent molecular weights. 3) The fine antigenic specificity of MC-P4 is different from those of anti-Leu 7 or MC-P2. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 101, 号 6, p. 382-389, 発行日 1987-06 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |