WEKO3
アイテム
{"_buckets": {"deposit": "e1cfd2f8-5b2c-42d5-921c-457254d8a500"}, "_deposit": {"id": "2231", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "2231"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00002231", "sets": ["454", "487"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "1470", "bibliographicPageStart": "1456", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "Organic \u0026 biomolecular chemistry"}, {"bibliographic_title": "Organic \u0026 biomolecular chemistry", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To provide insight into the polycyclization mechanism of squalene by squalene–hopene cyclase (SHC) from Alicyclobacilus acidocaldarius, some analogs of nor- and bisnorsqualenes were synthesized including the deuterium-labeled squalenes and incubated with the wild-type SHC, leading to the following inferences. (1) The deprotonation reaction for the introduction of the double bond of the hopene skeleton occurs exclusively from the Z-methyl group on the terminal double bond of squalene. (2) 3R-Oxidosqualene was folded in a boat conformation for the A-ring construction, while the 3S-form was in a chair structure. (3) The terminal two methyl groups are indispensable both for the formation of the 5-membered E-ring of the hopene skeleton and for the initiation of the polycyclization cascade, but the terminal Z-methyl group has a more crucial role for the construction of the 5-membered E-ring than the E-methyl group. (4) Some of the novel terpene skeletons, 36, 37, 39 and 40, were created from the analogs employed in this investigation.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Royal Society of Chemistry"}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1039/B401172D", "subitem_relation_type_select": "DOI"}}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1168650X", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "14770520", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hoshino, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "7568", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Schin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "7569", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Tomohiro"}], "nameIdentifiers": [{"nameIdentifier": "7570", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "7571", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyoshi, Aya"}], "nameIdentifiers": [{"nameIdentifier": "7572", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2_1456-1470.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "2_1456-1470.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/2231/files/2_1456-1470.pdf"}, "version_id": "104b5661-feb4-4301-83f9-2a280015ed9c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring"}, {"subitem_title": "Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "487"], "permalink_uri": "http://hdl.handle.net/10191/25025", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-02-07"}, "publish_date": "2014-02-07", "publish_status": "0", "recid": "2231", "relation": {}, "relation_version_is_last": true, "title": ["Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring"], "weko_shared_id": null}
Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring
http://hdl.handle.net/10191/25025
http://hdl.handle.net/10191/25025e8bfbdbc-9d6a-47a3-808f-f3e755d7c201
名前 / ファイル | ライセンス | アクション |
---|---|---|
2_1456-1470.pdf (2.0 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-02-07 | |||||
タイトル | ||||||
タイトル | Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hoshino, Tsutomu
× Hoshino, Tsutomu× Nakano, Schin-ichi× Kondo, Tomohiro× Sato, Tsutomu× Miyoshi, Aya |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To provide insight into the polycyclization mechanism of squalene by squalene–hopene cyclase (SHC) from Alicyclobacilus acidocaldarius, some analogs of nor- and bisnorsqualenes were synthesized including the deuterium-labeled squalenes and incubated with the wild-type SHC, leading to the following inferences. (1) The deprotonation reaction for the introduction of the double bond of the hopene skeleton occurs exclusively from the Z-methyl group on the terminal double bond of squalene. (2) 3R-Oxidosqualene was folded in a boat conformation for the A-ring construction, while the 3S-form was in a chair structure. (3) The terminal two methyl groups are indispensable both for the formation of the 5-membered E-ring of the hopene skeleton and for the initiation of the polycyclization cascade, but the terminal Z-methyl group has a more crucial role for the construction of the 5-membered E-ring than the E-methyl group. (4) Some of the novel terpene skeletons, 36, 37, 39 and 40, were created from the analogs employed in this investigation. | |||||
書誌情報 |
Organic & biomolecular chemistry en : Organic & biomolecular chemistry 巻 2, p. 1456-1470, 発行日 2004-12 |
|||||
出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14770520 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1168650X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1039/B401172D | |||||
著者版フラグ | ||||||
値 | publisher |