WEKO3
アイテム
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実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究
http://hdl.handle.net/10191/39333
http://hdl.handle.net/10191/393338e91f3dd-4513-460b-b851-886be690f5ee
名前 / ファイル | ライセンス | アクション |
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105(8)_548-553.pdf (1.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-10 | |||||
タイトル | ||||||
タイトル | 実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | focal cerebral ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calpain E-64c | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microtubule-associated protein 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 局所脳虚血 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 蛋白 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カルシウム依存性中性プロテアーゼ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | E-64 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 微小管関連蛋白 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Degradation of Cerebral Proteins and Effects of Protease Inhibitor in Experimental Cerebral Infarction | |||||
著者 |
犬塚, 貴
× 犬塚, 貴 |
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著者別名 | ||||||
識別子 | 130358 | |||||
識別子Scheme | WEKO | |||||
姓名 | Inuzuka, Takashi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using an immunoblotting technique, I investigated changes in the concentrations of microtubule-associated protein 2 (MAP 2), 200kD neurofilament, tubulin, myelin-associated glycoprotein (MAG) and 2':3'-cyclic nucleotide 3'-phosphodiesterase in the rats brains following occlusion of the left middle cerebral artery or sham operation. Compared with those 4 hours after surgery, concentrations of all proteins decreased significantly in the left hemisphere 3 days after surgery (p<0.01). Microtubule-associated protein 2 was the most susceptible to ischemia. Degradation products of MAP 2 and MAG were detected on the blots. Furthermore, in the contralateral himisphere, concentrations of these two proteins decreased comparing with those in concurrent sham-operated controls 3 days after surgery. Changes in the concentrations of cerebral proteins in the contralateral hemisphere are important for understanding clinical symptoms not attributable solely to the ipsilateral lesion following a focal cerebral stroke. Since MAP 2 is one of the substrate of calpain, E-64c, a synthetic calpain inhibitor, was administered at a dose of 400mg/kg twice a day for 3 days, with the first dose being given before the production of ischemia. The depletion of MAP 2 was significantly inhibited in vivo by E-64c (p<0.05). The results suggest that calpain is partially involved in the degradation of MAP 2, and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 105, 号 8, p. 548-553, 発行日 1991-08 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |