WEKO3
アイテム
{"_buckets": {"deposit": "19e13149-6214-4d21-9a0f-6177f552b202"}, "_deposit": {"id": "21087", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21087"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021087", "sets": ["456", "1176"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Ischemic Myocardium(Recent Advances in Therapy of the Ischemic Heart Disease)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "153", "bibliographicPageStart": "149", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In the ischemia of isolated perfused hearts, heart ceased its beating within 10min and creatine phosphate (CP) rapidly disappeared. ATP was decreased and disappeared around at 20min of ischemia. Intracellular pH was decreased from 7.2 to 6.0 until 20min of ischemia and sustained this value during the ischemic period. If the heart was reperfused at 15 min after ischemia, CP was recovered completely but, because of the loss of total adenine nucleotide contents, ATP was not. Intracellular Na^+ content was increased during ischemia and it is believed that this Na^+, in turn, increases Ca^\u003c2+\u003e content, a key substanoe of the irreversible damage of the myocardium, upon reperfusion. The course of Na^+ gain during ischemia was not fully understood. The responsibility of Na^+/H^+ exchange to this Na^+ gain has been suggested. Therefore, we have studied that whether or not Na^+/H^+ exchange operates during ischemia using its specific inhibitor, ethylisopropyl amirolide (EIPA). 10^\u003c-5\u003eM of EIPA which almost completely blocked Na^+/H^+ exchange during normoxia had no effect on the ischemia-induced pH change. Thus, we concluded that Na^+/H^+ exchanger did notoperate during ischemia.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "129332", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakazawa, Mikio"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "仲澤, 幹雄"}], "nameIdentifiers": [{"nameIdentifier": "129331", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(03)_149-153.pdf", "filesize": [{"value": "910.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 910600.0, "url": {"label": "106(03)_149-153.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21087/files/106(03)_149-153.pdf"}, "version_id": "b261ef09-50fc-4a27-a65f-bf51764219c5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "myocardial ischemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "energy metabolism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intracellular pH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+/H^+ exchange", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋虚血", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エネルギー代謝", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞内pH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+/H^+交換系", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会)"}, {"subitem_title": "1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1176"], "permalink_uri": "http://hdl.handle.net/10191/39574", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-14"}, "publish_date": "2016-03-14", "publish_status": "0", "recid": "21087", "relation": {}, "relation_version_is_last": true, "title": ["1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会)"], "weko_shared_id": null}
1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会)
http://hdl.handle.net/10191/39574
http://hdl.handle.net/10191/395743c180242-9685-40a8-9b21-c1a929223f1f
名前 / ファイル | ライセンス | アクション |
---|---|---|
106(03)_149-153.pdf (910.6 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-03-14 | |||||
タイトル | ||||||
タイトル | 1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 1) 基礎から見た虚血(シンポジウム 虚血心疾患の治療と最近の話題, 第470回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | energy metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intracellular pH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Na^+/H^+ exchange | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋虚血 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | エネルギー代謝 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞内pH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Na^+/H^+交換系 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Ischemic Myocardium(Recent Advances in Therapy of the Ischemic Heart Disease) | |||||
著者 |
仲澤, 幹雄
× 仲澤, 幹雄 |
|||||
著者別名 | ||||||
識別子 | 129332 | |||||
識別子Scheme | WEKO | |||||
姓名 | Nakazawa, Mikio | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the ischemia of isolated perfused hearts, heart ceased its beating within 10min and creatine phosphate (CP) rapidly disappeared. ATP was decreased and disappeared around at 20min of ischemia. Intracellular pH was decreased from 7.2 to 6.0 until 20min of ischemia and sustained this value during the ischemic period. If the heart was reperfused at 15 min after ischemia, CP was recovered completely but, because of the loss of total adenine nucleotide contents, ATP was not. Intracellular Na^+ content was increased during ischemia and it is believed that this Na^+, in turn, increases Ca^<2+> content, a key substanoe of the irreversible damage of the myocardium, upon reperfusion. The course of Na^+ gain during ischemia was not fully understood. The responsibility of Na^+/H^+ exchange to this Na^+ gain has been suggested. Therefore, we have studied that whether or not Na^+/H^+ exchange operates during ischemia using its specific inhibitor, ethylisopropyl amirolide (EIPA). 10^<-5>M of EIPA which almost completely blocked Na^+/H^+ exchange during normoxia had no effect on the ischemia-induced pH change. Thus, we concluded that Na^+/H^+ exchanger did notoperate during ischemia. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 3, p. 149-153, 発行日 1992-03 |
|||||
出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |