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デキストラン硫酸投与による実験的大腸炎の免疫学的検討 : 大腸粘膜局所での免疫担当細胞に関する動態
http://hdl.handle.net/10191/40054
http://hdl.handle.net/10191/40054762c478a-f012-46b9-88d7-5111c79563ac
名前 / ファイル | ライセンス | アクション |
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106(10)_949-959.pdf (2.9 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-25 | |||||
タイトル | ||||||
タイトル | デキストラン硫酸投与による実験的大腸炎の免疫学的検討 : 大腸粘膜局所での免疫担当細胞に関する動態 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | デキストラン硫酸投与による実験的大腸炎の免疫学的検討 : 大腸粘膜局所での免疫担当細胞に関する動態 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Experimental colitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dextran sulfate sodium (DSS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunocompetent cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 実験的大腸炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | デキストラン硫酸 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫担当細胞 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Immunological Study of Experimental Colitis Induced by Dextran Sulfate Sodium in Rats : Immunocompetent Cells in Colonic Mucosa | |||||
著者 |
滝澤, 英昭
× 滝澤, 英昭 |
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著者別名 | ||||||
識別子 | 127714 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takizawa, Hideaki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In order to clarify the etiology of inflammatory bowel diseases, some experimental animal models have been reported. Oral administration of dextran sulfate sodium (DSS) to rats is one of the models which resembles human ulcerative colitis in clinical course and pathological appearance. In this study, we assessed the dynamics of the immunocompetent cells in colitis mucosa induced by DSS. By oral administration of 3% DSS solutions, diarrhea started to occur in average 3.3 days after taking DSS, and bloody stool occurred in average 5.7 days after that. Pathological findings showed a remarkable cell infiltration in the colitis mucosa. Immunohistochemical study showed an increased number of CD4 T cells (W3/25), CD8 T cells (OX-8) and macrophages (Mar-1) without an increased number of histamine containing cells. Few activated T cells (5C6-F4) were observed in control mucosa but many activated T cells appeared in colitis mucosa. Luminol dependent chemiluminescence in peripheral blood was not different in intensity of a leukocyte between DSS rats and controls, but the chemiluminescence of mucosa of DSS rats showed higher intensity compared with that of controls. Furthermore, myeloperoxidase activity in mucosa of DSS rats was higher than that of controls. Tumor necrosis factor-like substance in the mucosa, which was assessed by ELISA, had a tendency to increase by administration of DSS. We also evaluated two drugs for the efficacy against this DSS model. Tranilast, which is an efficacious drug against immediate hypersensitivity, had no suppressive effects on mucosal lesions induced by DSS. On the other hand, FK506, a novel immunosuppressant, had a tendency to suppress the lesions and it affected the number of activated T cells in the mucosa. Moreover, FK506 had an suppressive effect to increae chemiluminescence activity, MPO activity and TNF-like substance. These date suggested that immunocompetent cells in colonic mucosa played an important part in the pathogenesis of colitis induced by DSS. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 10, p. 949-959, 発行日 1992-10 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |