WEKO3
アイテム
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5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)
http://hdl.handle.net/10191/38109
http://hdl.handle.net/10191/3810929f82cc1-b227-457d-b54c-b2ebe1643d5a
名前 / ファイル | ライセンス | アクション |
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108(3)_194-199.pdf (1.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-08 | |||||
タイトル | ||||||
タイトル | 5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SLE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiribosomal antibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lupus psychosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA-protein complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 全身性エリテマトーデス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗リボソーム抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ループス精神病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA 蛋白質複合体 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Anti-Ribosomal Autoantibodies in Patients with Systemic Lupus Erythematosus (Recent Progress in Autoimmune Diseases) | |||||
著者 |
佐藤, 健比呂
× 佐藤, 健比呂× 内海, 利男× 木南, 凌× 荒川, 正昭 |
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著者別名 | ||||||
識別子 | 121147 | |||||
識別子Scheme | WEKO | |||||
姓名 | Sato, Takehiro | |||||
著者別名 | ||||||
識別子 | 121148 | |||||
識別子Scheme | WEKO | |||||
姓名 | Uchiumi, Toshio | |||||
著者別名 | ||||||
識別子 | 6 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kominami, Ryo | |||||
著者別名 | ||||||
識別子 | 121150 | |||||
識別子Scheme | WEKO | |||||
姓名 | Arakawa, Masaaki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined sera from 90 active patients with systemic lupus erythematosus (SLE) for the presence of anti-ribosomal protein antibodies by Western-blotting, and also tested these sera for reactivity with ribosomal RNA (rRNA) by RNase T1 protection assay. Anti-P, anti-S10 and anti-L12 protein antibodies were detected in 38 (42%), 28 (31%) and 2 (2%) patients' sera, respectively. The anti-RNA antibody specific for the GTPase domain of 28S rRNA (anti-28S) was present in 15 (17%) sera. Cutaneous manifestations were dominant in anti-P, anti-S10 as well as anti-28S positive patients. Among 38 anti-P positive patients 3 developed acute lupus psychosis, and another 5 showed depression during their course of disease. These observations suggest that anti-ribosomal antibodies provide a useful marker for this disease. All anti-28S positive sera also contained anti-P activitiy and two of them have anti-L12 as well. There is no difference of anti-S10 frequency between anti-P positive sera and negative ones. It is therefore likely that strong association of three anti-ribosomal antibodies to the P proteins, L12 and GTPase domain of 28S RNA is due to an immune response against the limited RNA-protein complex domain in the ribodsome. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 3, p. 194-199, 発行日 1994-03 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |