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DNA修復機構の欠陥と神経細胞死 : 神経学的異常を伴う色素性乾皮症
http://hdl.handle.net/10191/38359
http://hdl.handle.net/10191/3835958c5dedd-4e74-4e13-a542-887a7983c303
名前 / ファイル | ライセンス | アクション |
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108(7)_481-484.pdf (639.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-17 | |||||
タイトル | ||||||
タイトル | DNA修復機構の欠陥と神経細胞死 : 神経学的異常を伴う色素性乾皮症 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | DNA修復機構の欠陥と神経細胞死 : 神経学的異常を伴う色素性乾皮症 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | xeroderma pigmentosum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nervous system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuron loss | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cerebral aging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alzheimer' s disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 色素性乾皮症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経系 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経細胞脱落 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脳の老化 (加齢) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アルツハイマー病 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | A Defect in DNA Repair and Neuronal Cell Death Xeroderma Pigmentosum with Neurological Abnormalities | |||||
著者 |
高橋, 均
× 高橋, 均× 柿田, 明美× 生田, 房弘 |
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著者別名 | ||||||
識別子 | 119875 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takahashi, Hitoshi | |||||
著者別名 | ||||||
識別子 | 119876 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kakita, Akiyoshi | |||||
著者別名 | ||||||
識別子 | 119877 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ikuta, Fusahiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Xeroderma pigentosum (XP) is a hereditary disease transmitted as an autosomal recessive trait characterized by a high incidence of sunlight-induced skin cancer, and frequent neurological abnormalities. It is well known that cells from XP patients have a defective DNA repair system. We studied neuropathologically two cases of XP with neurological abnormalities (De Sanctis-Cacchione syndrome). The pattern of topographical distribution and severity of neuron loss in the nervous system appeared to be similar to that seen in aged persons or patients with Alzheimer's disease. However, no senile plaques or neurofibrillary tangles were evident in the present cases. We consider that further studies of this human genetic disease are important for helping to clarify the mechanisms of neuronal cell death in normal cerebral aging as well as in Alzheimer's disease. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 7, p. 481-484, 発行日 1994-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |