WEKO3
アイテム
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4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)
http://hdl.handle.net/10191/43113
http://hdl.handle.net/10191/43113c7173623-75bb-4795-9518-32787a6f79f0
名前 / ファイル | ライセンス | アクション |
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110(6)_210-212.pdf (3.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-08-08 | |||||
タイトル | ||||||
タイトル | 4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-GBM nephritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glomerular endothelial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD8-positive lymphocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ICAM-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗糸球体基底膜型腎炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 糸球体内皮細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD8 陽性リンパ球 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | サイトカイン | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | A Cruicial Role of CD8-Positive Lymphocytes in Enhancement of ICAM-1 Expression on Glomerular Endothelial Cells in Crescentic Glomerulonephritis of WKY Rats (Recent Topics in Vascular Biology) | |||||
著者 |
藤中, 秀彦
× 藤中, 秀彦× 山本, 格 |
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著者別名 | ||||||
識別子 | 113448 | |||||
識別子Scheme | WEKO | |||||
姓名 | Fujinaka, Hidehiko | |||||
著者別名 | ||||||
識別子 | 113449 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yamamoto, Tadashi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mφ) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/Mφ in the glomeruli was examined. ICAM-1 expression and Mo/Mφ accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/Mφ were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/Mφ accumulation. Expression of mRNA for IL-1β, TNFα and IFNγ, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1β. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNFα and IFNγ and play a role in the accumulate Mo/Mφ. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 110, 号 6, p. 210-212, 発行日 1996-06 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |