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Newly Established Low Seizure Susceptible and Seizure-Prone Inbred Strains of Mongolian Gerbil
http://hdl.handle.net/10191/25127
http://hdl.handle.net/10191/25127eb93c196-aa4f-48f6-8a91-210da6b3545e
名前 / ファイル | ライセンス | アクション |
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52_2_169-172.pdf (28.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-02-12 | |||||
タイトル | ||||||
タイトル | Newly Established Low Seizure Susceptible and Seizure-Prone Inbred Strains of Mongolian Gerbil | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Newly Established Low Seizure Susceptible and Seizure-Prone Inbred Strains of Mongolian Gerbil | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epilepsy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gerbil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inbred strain | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
FUJISAWA, Nobuyoshi
× FUJISAWA, Nobuyoshi× MAEDA, Yoshitaka× YAMAMOTO, Yoshitaka× SATO, Norimitsu L.× NIIMURA, Sueo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Two inbred strains of the Mongolian gerbil with different phenotypes in seizure behaviour and coat color were newly established. LSAG/Nu has low seizure susceptibility and albino phenotypes, whereas SPBG/Nu has seizure-prone and black coat color phenotypes. LSAG was compared with SPBG as to seizure incidence and grade. Mean ages at seizure onset of LSAG and SPBG were 6 and 3 months, respectively. Seizure incidences in over 9 months old LSAG and SPBG gerbils were 37.3% (66/177) and 95.2% (118/124), respectively. LSAG has a significantly lower incidence (p<0.001) and grade (p<0.001) of seizures than SPBG. Only a few seizing LSAG gerbils exhibited myoclonus to tonic-clonic seizure progression. These results suggest that LSAG has some mechanisms which delay the onset of seizures and prevent them from becoming serious. Both strains of gerbils can be expected to be useful animal models for the study of human idiopathic generalized epilepsy. | |||||
書誌情報 |
Experimental animals en : Experimental animals 巻 52, 号 2, p. 169-172, 発行日 2003-12 |
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出版者 | ||||||
出版者 | 日本実験動物学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13411357 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11032321 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1538/expanim.52.169 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきJ-Stageから複製したものである | |||||
著者版フラグ | ||||||
値 | publisher | |||||
異版である | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/article/expanim/52/2/52_2_169/_pdf |