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We have recently reported that single nucleotide polymorphisms (SNPs) in the endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 (EDG1) gene were associated with marbling in Japanese Black beef cattle. As well as EDG1, the titin (TTN) gene, involved in myofibrillogenesis, has been previously shown to possess expression difference in musculus longissimus muscle between low-marbled and high-marbled steer groups, and to be located within genomic region of a quantitative trait locus for marbling. Thus TTN was considered as a positional functional candidate for the gene responsible for marbling. In this study, we explored SNP in TTN and analyzed association of the SNP with marbling. Findings: A SNP in the promoter region of TTN, referred to as g.231054C\u003eT, was the only difference detected between high- and low-marbled steer groups. 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Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle
http://hdl.handle.net/10191/30610
http://hdl.handle.net/10191/306108ee10688-c483-45ac-a989-77aa1d2dc4b3
名前 / ファイル | ライセンス | アクション |
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2_78.pdf (262.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-01 | |||||
タイトル | ||||||
タイトル | Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamada, Takahisa
× Yamada, Takahisa× Sasaki, Seiki× Sukegawa, Shin× Yoshioka, Sachiyo× Takahagi, Youichi× Morita, Mitsuo× Murakami, Hiroshi× Morimatsu, Fumiki× Fujita, Tatsuo× Miyake, Takeshi× Sasaki, Yoshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Marbling defined by the amount and distribution of intramuscular fat is an economically important trait of beef cattle in Japan. We have recently reported that single nucleotide polymorphisms (SNPs) in the endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 (EDG1) gene were associated with marbling in Japanese Black beef cattle. As well as EDG1, the titin (TTN) gene, involved in myofibrillogenesis, has been previously shown to possess expression difference in musculus longissimus muscle between low-marbled and high-marbled steer groups, and to be located within genomic region of a quantitative trait locus for marbling. Thus TTN was considered as a positional functional candidate for the gene responsible for marbling. In this study, we explored SNP in TTN and analyzed association of the SNP with marbling. Findings: A SNP in the promoter region of TTN, referred to as g.231054C>T, was the only difference detected between high- and low-marbled steer groups. The SNP was associated with marbling in 3 experiments using 101 sires (P= 0.004), 848 paternal half-sib progeny steers from 5 sires heterozygous for the g.231054C>T (P= 0.046), and 820 paternal half-sib progeny steers from 3 sires homozygous for C allele at the g.231054C>T (P= 0.051), in Japanese Black beef cattle. The effect of genotypes of the SNP on subcutaneous fat thickness was not statistically significant (P>0.05). Conclusion: These findings suggest that in addition to the EDG1 SNPs, the TTN SNP polymorphism is associated with marbling and may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle. Further replicate studies will be needed to confirm the allelic association observed here, and to expand the results to evaluate all possible genotypic combinations of alleles. | |||||
書誌情報 |
BMC research notes en : BMC research notes 巻 2, p. 78-1-78-6, 発行日 2009-05 |
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出版者 | ||||||
出版者 | BioMed Central | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17560500 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1186/1756-0500-2-78 | |||||
権利 | ||||||
権利情報 | (C) 2009 Sasaki et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
異版である | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.biomedcentral.com/content/pdf/1756-0500-2-78.pdf |