WEKO3
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1) 痴呆の分子機構(シンポジウム 「痴呆の病態と治療 : 分子生物学から地域医療までの統合」, 第545回新潟医学会)
http://hdl.handle.net/10191/46891
http://hdl.handle.net/10191/46891f5901c1a-4295-47b7-b4b5-544d0bee14d8
名前 / ファイル | ライセンス | アクション |
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113(10)_443-450.pdf (1.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-02-28 | |||||
タイトル | ||||||
タイトル | 1) 痴呆の分子機構(シンポジウム 「痴呆の病態と治療 : 分子生物学から地域医療までの統合」, 第545回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 1) 痴呆の分子機構(シンポジウム 「痴呆の病態と治療 : 分子生物学から地域医療までの統合」, 第545回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alzheimer disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic heterogenicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amyloid precursor protein gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | presenilin gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apolipoprotein E gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アルツハイマー病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アミロイド前駆体蛋白遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | プレセニリン遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アポリポ蛋白E遺伝子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Molecular Mechanisms of Dementia | |||||
著者 |
奥泉, 薫
× 奥泉, 薫× 辻, 省次 |
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著者別名 | ||||||
識別子 | 101376 | |||||
識別子Scheme | WEKO | |||||
姓名 | Okuizumi, Kaoru | |||||
著者別名 | ||||||
識別子 | 101377 | |||||
識別子Scheme | WEKO | |||||
姓名 | Tsuji, Shoji | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Advances in molecular genetic approaches have provided new insights into the pathogenesis of various neurodegenerative disorders with dementia. Alzheimer disease (AD) is by far the most common cause of dementia in human. Recent molecular genetic analyses have revealed that AD is etiologically heterogeneous. Early-onset familial AD has been demonstrated to be induced by mutations of the causative genes including amyloid precursor protein gene (APP), presenilin-1 (PS-1) and presenilin-2 (PS-2) genes. Initially, missense mutations of the gene encoding the amyloid precursor protein were identified as the causative mutations for AD. Subsequently, mutations of presenilin-1 and presenili-2 gene have been identified in a number of pedigrees with early-onset familial AD. Although these mutations have been found to be causative for familial forms of AD (FAD), the majority of AD occures as sporadic cases. Sporadic AD is demonstrated to be a polygenic disorder caused by several genetic risk factors. APOE 4, one of the alleles of the apolipoprotein E gene, has been established as being a major risk factor for sporadic and late-onset familial AD. Other risk factors are currently under investigation. The above mentioned studies strongly suggest the involvement of several key molecules in the pathogenesis of AD. Furthermore, it is strongly expected that preventive measures or new treatment methods for AD based on the genetic risk factors will be developed. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 113, 号 10, p. 443-450, 発行日 1999-10 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |