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MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討
http://hdl.handle.net/10191/48117
http://hdl.handle.net/10191/48117da5c932a-7487-4550-b5f5-5304bc4ed667
名前 / ファイル | ライセンス | アクション |
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115(4)_148-155.pdf (2.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-11-07 | |||||
タイトル | ||||||
タイトル | MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acoustic neurinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MIB-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proliferative potential | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regrowth | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 聴神経鞘腫 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 増殖能 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 再増大 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Proliferative Potential of Acoustic Neurinomas Evaluated by MIB-1 Labeling index | |||||
著者 |
任, 光旭
× 任, 光旭 |
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著者別名 | ||||||
識別子 | 96354 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ren, Guang-Xu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to assess the proliferative potential, i.e., tumor regrowth of acoustic neurinomas utilizing the monoclonal antibody MIB-1 labeling index (MIB-1 index). MIB-1 index were examined in 121 consecutive patients with unilateral acoustic neurinoma, 47 males and 74 females, ranging in age from 20 to 76 years. Of the 121 patients, 12 (9.9%) had tumor regrowth after the initial surgery, While none of 55 patients whose tumors were totally removed had no tumor regrowth, 12 (18.2%) of the other 66 patients having residual tumors had regrowth of the tumor. The mean MIB-1 index of specimen at the initial surgery (mean ± a standard deviation: 6.7 ± 4.3%) was significantly (p<0.05) higher in tumors with regrowth than in tumors without regrowth (1.6 ± 0.7%). The mean index of specimens from the intrameatal portion was significantly (p<0.05) lower than in those from the extrameatal portion. In the 66 patients with residual tumors, there was a significant (p<0.05) difference only in MIB-1 index between the patient groups with and without tumor growth. The level of MIB-1 index was significantly and independently associated with the occurrence of tumor growth (multiple linear regression analysis; standard B: 0.714; p<0.001). ln the patients with residual tumors, all of MIB-1 indexes in the tumors with regrowth were more than 3%, while all of those in the tumors without regrowth were less than 3%. The levels of MIB-1 index (log-%) were also significantly (r=-0.785; p<0.001) correlated with the time interval (log-years) between the initial and the second surgery. In 7 of 12 patients with tumor growth, from whom specimen could be obtained at the second surgery, no significant difference was observed in MIB-1 index between specimens at initial and second surgery. These data indicate that the levels of MIB-1 index of acoustic neurinoma at initial surgery seem useful to estimate the proliferative potential of acoustic neurinomas, i.e., the risk of tumor regrowth after initial surgery. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 4, p. 148-155, 発行日 2001-04 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |