WEKO3
アイテム
{"_buckets": {"deposit": "c14b47c0-fe24-4211-afa3-84b2117e8fd9"}, "_deposit": {"id": "14861", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14861"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014861", "sets": ["456", "1074"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Tridimensional Ventricular Analysis of Arrhythmogenecity of Long QT Syndrome(Differential effect of intracoronary acetylcholine injection in clinical cases and experimental models)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "256", "bibliographicPageStart": "245", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Intracoronary administration of acetylcholine (Ach) induced QTc interval prolongation in all 14 patients with congenital long QT syndrome (LQTS) and torsade de pointes arrhythmia developed following premature ventricular beats in 5 of the patients. In the experimental models of LQT 2 and LQT 3, tridimensional repolarization mapping showed that three layers having a different electrophysiological character existed in the left ventricle; endocardial (End), midmyocardial M-cell (Mid) and epicardial layer (Epi). The refractory period estimated by the activation-recovery interval (ARI) in the Mid layer was longer than that at Epi/End layers, so marked transmural ARI dispersion was created especially between the Mid and Epi layers at the longer basic drive of 60 bpm. The marked transmural dispersion of repolarization was diminished when the pacing rate changed to 100 bpm. Different from the clinical LQTS patients, intracoronary Ach administration in the LQT models did not show any QTc interval prolongation at lower concentrations. Further, at higher concentrations (>5μg) of Ach, the Epi layer showed greater ARI abbreviation rather than the Mid/End layers which resulted in greater transmural dispersion of repolarization, but no ventricular arrhythmia was induced.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "95812", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kasai, Hidehiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "笠井, 英裕"}], "nameIdentifiers": [{"nameIdentifier": "95811", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(6)_245-256.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "115(6)_245-256.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14861/files/115(6)_245-256.pdf"}, "version_id": "ce3dfda5-c534-478d-bfe6-bfcb85c2dbe9"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Long QT Syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "M-cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "acetylcholine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "QT延長症候群", "subitem_subject_scheme": "Other"}, {"subitem_subject": "M細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アセチルコリン", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に"}, {"subitem_title": "先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1074"], "permalink_uri": "http://hdl.handle.net/10191/48255", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-09"}, "publish_date": "2017-11-09", "publish_status": "0", "recid": "14861", "relation": {}, "relation_version_is_last": true, "title": ["先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に"], "weko_shared_id": null}
先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に
http://hdl.handle.net/10191/48255
http://hdl.handle.net/10191/48255b54af38d-ca64-4f37-9cbf-ddaa3550d791
名前 / ファイル | ライセンス | アクション |
---|---|---|
115(6)_245-256.pdf (2.4 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-11-09 | |||||
タイトル | ||||||
タイトル | 先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Long QT Syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | M-cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acetylcholine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | QT延長症候群 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | M細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アセチルコリン | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Tridimensional Ventricular Analysis of Arrhythmogenecity of Long QT Syndrome(Differential effect of intracoronary acetylcholine injection in clinical cases and experimental models) | |||||
著者 |
笠井, 英裕
× 笠井, 英裕 |
|||||
著者別名 | ||||||
識別子 | 95812 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kasai, Hidehiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Intracoronary administration of acetylcholine (Ach) induced QTc interval prolongation in all 14 patients with congenital long QT syndrome (LQTS) and torsade de pointes arrhythmia developed following premature ventricular beats in 5 of the patients. In the experimental models of LQT 2 and LQT 3, tridimensional repolarization mapping showed that three layers having a different electrophysiological character existed in the left ventricle; endocardial (End), midmyocardial M-cell (Mid) and epicardial layer (Epi). The refractory period estimated by the activation-recovery interval (ARI) in the Mid layer was longer than that at Epi/End layers, so marked transmural ARI dispersion was created especially between the Mid and Epi layers at the longer basic drive of 60 bpm. The marked transmural dispersion of repolarization was diminished when the pacing rate changed to 100 bpm. Different from the clinical LQTS patients, intracoronary Ach administration in the LQT models did not show any QTc interval prolongation at lower concentrations. Further, at higher concentrations (>5μg) of Ach, the Epi layer showed greater ARI abbreviation rather than the Mid/End layers which resulted in greater transmural dispersion of repolarization, but no ventricular arrhythmia was induced. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 6, p. 245-256, 発行日 2001-06 |
|||||
出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |