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アルポート症候群モデルマウスに対する薬物療法の検討
http://hdl.handle.net/10191/2651
http://hdl.handle.net/10191/26514e74a3ea-c90e-441d-b7e0-b715e666ac33
名前 / ファイル | ライセンス | アクション |
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KJ00000141921.pdf (2.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | アルポート症候群モデルマウスに対する薬物療法の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | アルポート症候群モデルマウスに対する薬物療法の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alport syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | knockout mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclosporin A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensin converting enzyme inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tenascin-C | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Effects of Two Immunosuppressants, Cyclosporin A and Mizoribime, and Angiotansin Converting Enzyme Inhibitor, Enalapril on Alport Model Mice | |||||
著者 |
伊東, 達雄
× 伊東, 達雄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Effective pharmacotherapy in Alport syndrome has not yet been established. In this study, the efficiency of two immunosuppressants cyclosporin A (CyA) and mizoribine (MZR), and angiotensin converting enzyme inhibitor (ACEi), enalapril was examined using Col4 α 4 knockout mice as a model of this disease. CyA (10mg/kg/day), MZR (50mg/kg/day) and enalapril (18mg/kg/day) were administered everyday from three weeks of age. The CyA and enalapril treatments suppressed the elevation of proteinuria at 8 and 12 weeks of age and significantly inhibited the crescent formation at 12 weeks of age. The enalapril treatment could prolong the lives of Col4 α 4 mutant mice significantly, i.e, 26.3±6.2 weeks (mean±SD) of the treated mice vs. 18.3±3.9 weeks of the untreated control mice, whereas the CyA treatment failed to prolong the life span. Taken together, enalapril is considered to have a beneficial effect on the Alport model mice. This effect may be brought about by the improvement of renal hemodynamics and the suppression of an antiadhesion factor tenascin. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 116, 号 7, p. 324-336, 発行日 2002-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |