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ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在
http://hdl.handle.net/10191/2557
http://hdl.handle.net/10191/25578631574e-699e-41da-8263-c31a883825c9
名前 / ファイル | ライセンス | アクション |
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KJ00000141919.pdf (1.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PAI-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | t-PA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | STZ-induced diabetic rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kidney | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Regulation of Plasminogen Activator Inhibitor type1 (PAI-1) and Tissue Plasminogen Activator (t-PA) Expression in Streptozotocin-induced Diabetic Rats: Expression in Systemic Organs and Localization in the Kidney | |||||
著者 |
上村, 宗
× 上村, 宗 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Expression of mRNAs for plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) was examined in systemic organs of normal and streptozotocin (STZ)-induced diabetic rats by using RNase protection assay. PAI-1 mRNA was expressed in the whole eye, lung, myocardium, aorta, and kidney in normal rats while it was not detected or under detection level in the whole brain, liver and skeletal muscle. In diabetic rats, the level of PAI-1 mRNA increased in all the organs expressing PAI-1 mRNA except for the kidney. t-PA mRNA was expressed in the whole brain, whole eye, lung, myocardium, and kidney and, in diabetic rats, its level was found to be increased except for that in the kidney. The expression pattern in systemic organs of normal rats and its change in diabetic rats was quite similar between PAI-1 and t-PA mRNAs, suggesting their implications in the development of microangiopathy characteristic of diabetes mellitus. PAI-1 and t-PA mRNA expression in the kidney was found to be highly enriched in the glomeruli of both normal and diabetic rats. Double immunofluorescence staining with monoclonal antibody (mAb 5-1-6) against slit diaphragm revealed the co-localization of anti-PAI-1 antibody and mAb 5-1-6. These results suggests that the glomerular epithelial cells is the major cells in producing PAI-1 in the kidney. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 116, 号 7, p. 306-316, 発行日 2002-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |