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心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節
http://hdl.handle.net/10191/47933
http://hdl.handle.net/10191/479334541e0ad-4b44-4b8c-a941-c64e757ef098
名前 / ファイル | ライセンス | アクション |
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131(3)_160-172.pdf (1.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-09-22 | |||||
タイトル | ||||||
タイトル | 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心肥大 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 選択的スプライシング | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低酸素 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Regulation of Alternative Splicing of Titin, CaMKIIδand ZASP/Cypher mRNAs in Heart Disease | |||||
著者 |
焦, 爽
× 焦, 爽 |
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著者別名 | ||||||
識別子 | 58301 | |||||
識別子Scheme | WEKO | |||||
姓名 | Jiao, Shuang | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [Objectives] Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKII δ and ZASP/Cypher genes changes in hearts under pathological stress conditions. [Methods] The alternative splicing of titin, CaMKII δ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients, monocrotaline pulmonary hypertension rats and in cardiomyocytes cultured under hypoxic conditions. [Results] Large N2BA-titin, cytoplasmic CaMKII δ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and cytoplasmic CaMKII δ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions, PGM1-binding ZASP/Cypher isoforms significantly increased, but large N2BA-titin and cytoplasmic CaMKII δ isoforms decreased, compared with cells under normoxic conditions. [Conclusions] The alternative splicing of titin, CaMKII δ and ZASP/Cypher genes was markedly modulated in hearts under pathological stress conditions and may be involved in adaptations to pathological changes. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 131, 号 3, p. 160-172, 発行日 2017-03 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |