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Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM)
http://hdl.handle.net/10191/33311
http://hdl.handle.net/10191/333114cbb8cb8-4f17-47be-810a-e63e69defaf0
名前 / ファイル | ライセンス | アクション |
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41(1)_1-9.pdf (2.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-09-11 | |||||
タイトル | ||||||
タイトル | Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Nishi, Shinichi
× Nishi, Shinichi× Arakawa, Masaaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studies have revealed highly differentiated structures and functions of glomerular basement membrane (GBM). The most specific feature of the GBM is a three-layer structure, i.e. a lamina densa and two laminae rarae. The GBM consists of various components, such as type IV collagen, laminin and proteoglycans, in forming its three-dimensional network structure. This structure is thought to result from a self-assembling of each component and binding each other. The subclasses of the components have been differentiated and their distributions have been proved to be heterogeneous with the GBM. These structural characteristics are supposed to be related to the function of the GBM as a sieving membrane and as a base for cellular attachment. The mechanism of pathological damage to the structure and function of the GBM has been elucidated in various renal diseases with advances in the basic studies on the GBM. Matrix metalloprotainase (MMP) is considered to be important in GBM injuries of IgA nephropathy. Glycosylation of GBM components is suggested to be one of the causes of thickening of the GBM. A genetic mutation in α5(IV) chain of type IV collagen has been confirmed in Alport's syndrome. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 41, 号 1, p. 1-9, 発行日 1993-03 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |