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In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p \u003c0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. 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PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine
http://hdl.handle.net/10191/33134
http://hdl.handle.net/10191/33134d09f95d6-6698-4459-9f30-7330f0752faa
名前 / ファイル | ライセンス | アクション |
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45(4)_143-151.pdf (1.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-25 | |||||
タイトル | ||||||
タイトル | PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endocrine cell tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carcinoid tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endocrine cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | large intestine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PCNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nuclear morphometry | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Nishikura, Ken
× Nishikura, Ken× Watanabe, Hidenobu× Iwafuchi, Mitsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Endocrine cell tumors of the gastrointestinal tract are divided into the carinoid tumor (CD), a low-grade malignancy, and endocrine cell carcinoma (ECC), a high-grade malignancy. In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p <0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. Conclusions: Nuclear morphometry and PCNA index are useful for distinguishing CDs from more malignant CDs or ECCs, and for detecting the progressive potentiality of CDs. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 45, 号 4, p. 143-151, 発行日 1997-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |