Second Primary Cancer Developing in the Reconstructed Gastric Tube sfter Esophagectomy for Esophageal Cancer: Clinicopathological Analyses of 14 Cases
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Background and Objectives : To clarify the clinicopathologic features and determine the adequate management of a second primary carcinoma developing in the reconstructed gastric tube (CRGT) after esophagectomy for esophageal cancer, clinical and pathological records of 14 patients with CRGT were reviewed. Methods : A total of 14 cases of CRGT were divided into 9 cases of early (T1) CRGT and 5 cases of advanced (T2 or more extensive) CRGT according to the depth of tumor invasion. Results : All of the 9 patients with early CRGT were asymptomatic, and the cancer was detected on follow-up endoscopic examination, whereas 4 of the 5 patients with advanced CRGT presented symptoms. The majority of the patients with early CRGT were treated by means of endoscopic mucosal resection with or without a combination of laser ablation or partial resection of the gastric tube. The 5-year survival rate for patients with early CRGT was 71%, whereas none of the patients with advanced CRGT survived more than one year, regardless of the type of treatment. There was a significant difference (P=0.0014) between the survival curves for the two patient groups. Conclusions : Postoperative endoscopic examination may be useful for the early detection and favorable treatment results in patients with CRGT after esophageal replacement for esophageal cancer.
Second Primary Cancer Developing in the Reconstructed Gastric Tube sfter Esophagectomy for Esophageal Cancer: Clinicopathological Analyses of 14 Cases
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