WEKO3
アイテム
{"_buckets": {"deposit": "b67ad52c-530e-4359-98cb-05f878752bf3"}, "_deposit": {"id": "5857", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5857"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005857", "sets": ["455", "562"]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "(0bjectives)Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes changes in hearts under pathological\\nstress conditions. (Methods)The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients,monocrotaline pulmonary\\nhypertension rats and in cardiomyocytes cultured under hypoxic conditions.(Results) Large N2BA-titin, cytoplasmic CaMKIIδ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and cytoplasmic CaMKIIδ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions,\\nPGM1-binding ZASP/Cypher isoforms significantly increased, but large\\nN2BA-titin and cytoplasmic CaMKIIδ isoforms decreased, compared with cells under normoxic conditions. (Conclusions) The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes was markedly modulated in hearts under\\npathological stress conditions and may be involved in adaptations to pathological changes.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士(医学). 報告番号: 甲第4269号. 学位記番号: 新大院博(医)甲第747号. 学位授与年月日: 平成29年3月23日", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第747号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4269号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50994", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Jiao, Shuang"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "焦, 爽"}], "nameIdentifiers": [{"nameIdentifier": "50993", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h28nmk747.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/5857/files/h28nmk747.pdf"}, "version_id": "42e87d1c-1423-4850-b8f9-5b54a4442b05"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h28nmk747_a.pdf", "filesize": [{"value": "205.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 205500.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/5857/files/h28nmk747_a.pdf"}, "version_id": "36bbd75b-7254-4e33-849f-d5819713e41b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "心筋炎", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心肥大", "subitem_subject_scheme": "Other"}, {"subitem_subject": "選択的スプライシング", "subitem_subject_scheme": "Other"}, {"subitem_subject": "低酸素", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節."}, {"subitem_title": "心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/47614", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-06-13"}, "publish_date": "2017-06-13", "publish_status": "0", "recid": "5857", "relation": {}, "relation_version_is_last": true, "title": ["心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節."], "weko_shared_id": 2}
心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.
http://hdl.handle.net/10191/47614
http://hdl.handle.net/10191/47614cd2f9310-35eb-4f7d-826e-7623c9b5ef4d
名前 / ファイル | ライセンス | アクション |
---|---|---|
本文 (1.5 MB)
|
|
|
要旨 (205.5 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-06-13 | |||||
タイトル | ||||||
タイトル | 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節. | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心肥大 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 選択的スプライシング | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低酸素 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
著者 |
焦, 爽
× 焦, 爽 |
|||||
著者別名 | ||||||
識別子 | 50994 | |||||
識別子Scheme | WEKO | |||||
姓名 | Jiao, Shuang | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | (0bjectives)Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes changes in hearts under pathological\nstress conditions. (Methods)The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients,monocrotaline pulmonary\nhypertension rats and in cardiomyocytes cultured under hypoxic conditions.(Results) Large N2BA-titin, cytoplasmic CaMKIIδ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and cytoplasmic CaMKIIδ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions,\nPGM1-binding ZASP/Cypher isoforms significantly increased, but large\nN2BA-titin and cytoplasmic CaMKIIδ isoforms decreased, compared with cells under normoxic conditions. (Conclusions) The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes was markedly modulated in hearts under\npathological stress conditions and may be involved in adaptations to pathological changes. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4269号. 学位記番号: 新大院博(医)甲第747号. 学位授与年月日: 平成29年3月23日 | |||||
書誌情報 | 発行日 2017-03-23 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4269号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第747号 |